Divalproex Lab Report
Evidence Based Answer: Gabapentin and divalproex are both effective anticonvulsant medications for partial seizures in female adolescent patients1,2. However, divalproex has adverse effects that are detrimental to patients with preexisting liver impairment3. Gabapentin does not have these detrimental effects on the liver like divalproex does because it is eliminated from the body through the kidneys instead of the liver4. If divalproex is more effective for the patient than gabapentin it may be paired with diammonium glycyrrhizinate to combat the detrimental effects on the liver. This is combination is new and has only been tested with mice but has shown effectiveness in preventing and alleviating VAP-induced hepatotoxicity3. Evidence Summary: Divalproex is a drug that is metabolized by the liver and excreted through the kidneys1. Since the drug is metabolized by the liver it can lead to VAP-induced hepatotoxicity. …show more content…
Diammonium glycyrrhizinate is the active chemical found in liquorice root. It has been used in Asian countries in order to combat liver diseases that have been induced by chemical and drug toxicity3. In a recent study it was tested for combating VAP-induced hepatotoxicity. The experiment was performed in mice and shows promising results for the use of diammonium glycyrrhizinate with divalproex in order to counter the effects of VAP-induced hepatotoxicity. In the study, mice that were treated with diammonium glycyrrhizinate and divalproex had liver enzyme counts closer to the control group than the group receiving just divalproex. It was also shown that diammonium glycyrrhizinate suppresses Keap1 therefore allowing Nrf2 to protect the hepatic cells from the increase in antioxidants. It also decreased the levels of NF-kappa B in order to decrease inflammation due to the proinflammatory
Nt1310 Unit 9 Lab Report
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Unknown Culture Lab Report
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Divalproex Case Study
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Unknown Lab Report
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628 Words | 3 PagesIt is not uncommon for individuals, particularly within the United States to be prescribed antidepressants, prescription sleep medications, pain killers, and a slew of other overly prescribed medications at one point of their lives. In the course of over a half century period pharmaceutical companies have shifted gears toward the research and production of prescription drugs tailored for chronic conditions. In the essay review, “Understanding the “Therapeutic Embrace” between Big Pharma and Modern Medicine”, author Michael Oldani outlines this phenomena. The subject of his book review is a work by Jeremy A. Greene, author of Prescribing by Numbers: Drugs and the Definition of Disease.
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Biology Unit 9
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Pt1420 Unit 6 Lab Report
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Our Satisfaction Scores For Satisfaction If Patients Only Had Time Heparin Subcutaneous Injection
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Biochemical Test Lab Report
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