Angelman and Prader-Willi syndromes are congenital diseases, present from birth, and are a result of chromosomal abnormalities. Two common proximal deletion breakpoint regions exist in both of the syndromes; this deletion mechanism is the same one that accounts for paternal and maternal deletions. PWS is caused by an absence of a paternal contribution in the chromosome 15q11.2–q13 region, while AS is due to an absence of a maternal contribution in the same region Leff et al. (1992) suggests that Prader-Willi syndrome is a result of missing genes on a maternal chromosome because of its association with parental gene deficiencies in chromosome 15q11.2–q13 region. Snrpn gene on a human chromosome 15q11–13 coding for a brain enrinched small nuclear ribonucleoprotein (snRNP)-associated polypeptide SmN was mapped to chromosome 7 in mouse (Leff et al, 1992).This experiment established that Snrpn is a maternally imprinted gene in mice.
I had a caseload of six patients to care for under the supervision of a staff nurse. The patients were both preoperative and postoperative a variety of colorectal surgeries. The event relates to a 38 year old male patient who I received to the ward from theatre post left inguinal lymph node excision and biopsy. The theatre nurse who transferred the patient to the ward provided me with a detailed handover of the patient and post-operative instructions given by the surgeons and anaesthetists. This included postoperative observations as per HSE guidelines (HSE 2010) of both vital signs and wound site observations, which were to be conducted at regular intervals.
Brooke Martin Report #2 - Prader-Willi Syndrome Prader-Willi Syndrome, an imprinted disorder, is caused by the absence of paternal chromosome fifteen, at least in approximately seventy percent of all cases. In other unlikely cases, a child may have inherited two copies of chromosome fifteen from its mother, which is referred to as maternal uniparental disomy. Similarly, in vitro fertilisation may increase the risk of a mother birthing a child with an imprinted disorder. PWS can cause delayed development, low muscle strength and tone, stunted growth, difficulties feeding, obesity, infertility, and behavior problems. Infants with PWS have “insatiable appetites” which causes them to overeat and can result in obesity into adulthood, and even death,
operative time and complications and postoperative outcomes e.g. ; time to full feedings, incidence of postoperative vomiting, hospital stay and wound dehiscence were recorded. The study was approved by the Research Ethics Committee of the pediatric surgery department, Faculty of Medicine, Cairo University. Informed written consent was obtained from the parents of all patients. Every patients guardian was asked to give a score of his / her satisfaction regarding the cosmetic appearance of the scar and an overall grading regarding how he / she feels about this kind of technique and weather he /she feels his /her child had become normal or not after the operation.
attenuated the elevated plasma glucose in diabetic mice, increased glucose utilization, delayed the development of insulin resistance and then enhanced insulin sensitivity. The activation of insulininduced IR-Akt-GLUT2 expression in liver and the enhancement of insulin sensitivity may have contributed to the hypoglycemic
Prior to surgical procedure, routine hematological examinations were done and all the values were found to be within normal limits. The patient deprived of any history of NSAID use prior to her surgical procedure. She also denied taking any herbal medications. Scaling & Root planing were performed at the initial appointment, and a few days later, a periodontal flap surgery procedure was planned to treat the site. The patient was given oral antibiotics, analgesics and antiseptic mouthwash for 5
When the pleura form fibrous tissues due to an inflammatory process that restricts lung expansion, surgeons perform decortication, which aims to peel off the hardened tissue. This results in the return of lung compliance, which leads to improvement of symptoms. Newer techniques include video-assisted thoracoscopic surgery or VATS decortication, which is a less invasive method that uses a small camera to guide thin instruments through small skin
Oral hypoglycemic agents were omitted on day of surgery and started after surgery day or at time of discharge or replaced by insulin. In few cases, oral hypoglycemic agents were continued on the day of surgery deviating from literature. In majority of cases insulin was given on the day of surgery (STAT dose was given based o the GRBS). Certain target blood glucose levels were set by the physician which was patient specific and insulin dose was adjusted based on those levels. If blood glucose levels were within the target range insulin was omitted and if not, STAT dose with short acting insulin was given based on GRBS values through intravenous route.
I was no longer under the guidance of anyone, I was discussing patients with the doctors, I was ringing up the psychology team to review my anorexic patient, I was involved with all members of the multidisciplinary team. I asked for help at one stage with getting a post- operative appendectomy patient out of the bed and my preceptor had told me she would be down to help in a few minutes. As time passed she was nowhere to be seen which meant the post-operative patient remained in the bed. It was pivotal that this patient was mobilising by that afternoon to distinguish whether he was being discharged or
Lu- Yao GL.,Barry MJ, Chang CH: Transurethral resection of prostate among medicare beneficiaries in the United states: Time treads and outcomes Prostate Patient Outcomes Research Team (PORT). Urology 1994; 44:692-698. 9. Jonler, M: Rickman, M: Brushiest. R.C.