In the 1960s, Grünenthal GmbH developed tramadol. It has an analgesic potency that is about one tenth of that of morphine. In addition to its pain relieving properties, it has anti-depressive and anxiolytic properties (Kusari ,S., etall,2015). Tramadol 's metabolism occurs in the liver by demethylation, which is mediated by CYP3A4 and CYP2B6, glucuronidation, and sulfation. Metabolism of tramadol via CYP2D6 result in the generation of an active metabolite
To determine and compare the sedative and anxiolytic effects of orally administered Alprazolam and Lorazepam in control and treatment group at time intervals of 30, 60 and 90 minutes. 2. To determine and compare the degree of psychomotor and cognitive impairment that may have resulted from the administration of Alprazolam and lorazepam. 3. To determine and compare the quality of recovery from the anesthetic administered with the Alprazolam and Lorazepam as premedication.
1.0 Introduction Tritace is an Angiotensin-Converting-Enzyme (ACE) Inhibitor. It is used to treat hypertension, heart failure, stroke, myocardial infarction and diabetes. Its generic name is Ramipril. Other brand names include Altace, Cardace, Ramiril and Ramacor. Some examples of other ACE Inhibitors are Enalapril, Quinapril, Captopril and Lisinopril.
One tablet contains 250mg of aspirin, 250mg of acetaminophen and 65mg of caffeine. These three compounds in combination are said to be effective against migraine headaches. Aspirin, or acetylsalicylic acid, is an analgesic and an anti-inflammatory and has an important role in preventing cardiovascular disease (Ji Ma, 2017). Caffeine is a stimulant and is the most consumed psychoactive substance in the world. Paracetamol, or acetaminophen is also an analgesic and an antipyretic (Revell,
The buoyancy lag time in simulated gastric fluid (0.1 mol L-1 HCL, pH 1.2) varied with the formulation variable. Formulation P1 exhibited the least buoyancy lag time (26 s) while formulation P6 exhibited the highest lag time (219 s). The decrease in the buoyancy lag time of a formulation P1 can be attributed to the availability of an increased amount of carbon dioxide as the with concentration of calcium carbonate which was entrapped in the formed gel to give rapid buoyancy. Irrespective of formulation variables, buoyancy duration was >12
1. Background Caspofungin is an echinocandin antifungal agent licensed as a first-line therapy for invasive candidiasis in patients with moderate to severe illness or recent exposure to azoles . Caspofungin acts by inhibiting the synthesis of (1,3)-β-D-glucan of the fungal cell wall, ultimately causing cell death . The recommended dosage regimen of caspofungin is a loading dose of 70 mg followed by 50 mg daily (70/50 mg), administered intravenously over 1 h. Caspofungin is highly protein bound (~ 96%) and metabolizes slowly in the liver [3-5]. Its liver uptake is a biphasic process and its binding to the surface of hepatocytes is fast and reversible.
All the above agents are non-selective inhibitors for the neutrophil driven inflammation that occurs in acute gout. 1. Colchicine - Colchicine has been found to be efficacious when compared to placebo in randomised controlled trial. It has also been very clearly confirmed that high and low dose of colchicine has similar effectiveness, but low dose of colchicine carries a better safety profile as compared to the high dose. Accordingly, high dose of colchicine should be avoided which carries significant gastrointestinal side effects.
This shows that esomeprazole is more effective in the body. The AUC decreases after consumption.iv The bioavailability of esomeprazole is 68% while the bioavailability of omeprazole is 20%. Therefore, esomeprazole is suggested to be more effective than omeprazole. Esomeprazole 20 mg and 40 mg was shown to have a better healing capability during the eighth week than omeprazole 20 mg in patients with gastroesophageal reflux disease. Over a four week therapy, it was shown that esomeprazole has very little value over omeprazole.
Background: Adjuncts to local anaesthetics for brachial plexus block may enhance the quality and duration of analgesia. Midazolam, a water-soluble benzodiazepine, is known to produce antinociception and enhance the effect of local anaesthetics when given epidurally or intrathecally. Aim: Study was to assess the effect of Midazolam added to brachial plexus block by supraclavicular approach. Materials and Methods: A prospective, randomized, single blinded study was conducted on 100 ASA Grade I or II adult patients undergoing upper limb surgeries under supraclavicular brachial plexus block. Patients were randomly divided into two groups.