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Drug Delivery Advantages

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Joined to the oesophagus via the lower oesophageal sphincter, the stomach is present as a part of the gastro-intestinal tract (GIT). It serves as a temporary depot of food, mechanically breaks down food into tinier particles, aids in the digestion of proteins and controls the flow of chyme into the duodenum.1The stomach is further subdivided into fundus, body, antrum and pylorus. Gastric emptying results from the net effects of propulsive forces within the stomach and the resistance to flow offered by the pyloric sphincter.2 The gastro-intestinal (GI) motility is associated with cyclic contractile actions while in fasting condition, which is known as migrating myoelectric complex (MMC) that occur every 1.5 to 2 h. Hence, the gastric residence …show more content…

Floating drug delivery helps the drug to remain at the site of absorption and thus it enhances the bioavailability.
Sustained drug …show more content…

But floating drug delivery remains in the stomach for longer period of time to their increased gastric retention. In many cases of modified release capsules it has been observed that the major portion of drug releases in the colon rather than stomach. However prolongation in the GRT may sustain the release of drug.30
Site specific drug delivery:
Some drugs like furosemide and riboflavin are having their absorption site in the upper small intestine so they are typically formulated as floating dosage forms. Floating drug delivery serves an excellent drug delivery for the treatment of Helicobacter pylori, which causes gastric and peptic ulcers. The treatment needs high drug concentration of drug to be maintained at the site of infection that is within the gastric mucosa. Because of their floating ability these dosage forms can be retained in the gastric region for long period of time so that the drug can be targated.30
Lesser side effects:
These dosage forms keep the drug away from the lower GI tract which can be harmfull to intestinal flora. The lower peak concentrations can also reduce adverse pharmacological

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