Dynein Motor Protein Research Paper

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Cell Biology BI309 Mini-Review 1 Title: Dynein Motor Proteins

In order for eukaryotic cells to be motile they use motor proteins that are propelled by ATP. There are three classes of motor proteins; myosin, kinesin and dynein. Dynein is the motor protein to be discussed in detail for this review. Dynein is a large and complex motor protein found in microtubules of cilia and flagella that causes movement due to the conversion of Adenosine Triphosphate(ATP) which is a form of chemical energy to mechanical energy i.e. movement. Due to the large mass of the dynein protein, it has been quite a challenge to explain the function and mechanism of dynein. Through experimentation developments have been made in recent years into comprehending how dynein
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Dynein is a popular research topic at the moment as there is not much as much information on it as there is of the other motor proteins kinesin and myosin. Dynein is a member of the AAA+ class. Like the other members of this AAA+ class, dynein has a ring structure of AAA+ modules at the centre. However, unlike the other molecules in this super family, dynein is unique because it forms a polypeptide as well as other large particles or structures. (Roberts et al,…show more content…
In particular there are many cilia and flagella present in the lung. Axonemes make up the cilia and flagellum. They are present in 9 sets of doublets. As shown in Figure 1.1 (a). Axonemal dynein proteins are attached to doublets on the inner and outer arms. Although axonemal dyneins are present in the axoneme, they are not fundamental in the formation of axonemes. Inner arms have six of one heavy chain dynein with one head and one of a one heavy chain dynein with two heads. This is a pattern that repeats itself every 96nm. On the outer arms the dyneins are the same with three different heavy chains. The dynein also has a flexible stem, globular head as well as a thin string with the ATP binding site. Axonemal dynein proteins cause microtubules to move and thus the cilia and flagella move by a beating process. Cilia and flagella have very similar structure so it is very difficult to distinguish them from each other at times. However we can distinguish between them from their movement. Flagella move in a wave like motion where as cilia move in a sling shot motion. When multiple cilia move at the same time in the same direction. Large cargoes can be moved quickly. Cilia move or "beat" one hundred times per second. (Pollard et al,

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