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Dexmedetomine Vs Esmol

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COMPARISON OF INTRAVENOUS DEXMEDETOMIDINE VERSUS ESMOLOL FOR ATTENUATION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION Abstract: Background: Esmolol has an established role in attenuation of hemodynamic response to laryngoscopy and endotracheal intubation. We studied the effect of Dexmedetomidine compared to that of esmolol in this study. Aim: To study the role of dexmedetomine in attenuation of hemodynamic response to laryngoscopy and oral endotracheal intubation compared to that of esmolol hydrochoride in patients posted for elective surgery under general anesthesia. Study Design: Prospective randomized study-double dummy blinding method Material and Methods: 60 ASA I patients, aged 18-60 years randomly divided into two groups; Group A patients received dexmedetomidine 1mcg/kg diluted in 50ml …show more content…

Dexmedetomidine has unique pharmacokinetics making it difficult to compare with other routinely used drugs like esmolol and lignocaine. We adopted a unique blinding technique-double dummy method to make this comparison between dexmedetomidine and esmolol possible in a ideal manner. We hypothesized that intravenous dexmedetomidine 1mcg/kg administered over 10mins prior to endotracheal intubation would attenuate the hemodynamic response to laryngoscopy and endotracheal intubation more effectively than intravenous esmolol 0.5mg/kg given as a bolus dose two minutes prior to intubation. This prospective, randomized, double blinded study was attempted to study and compare the effect of dexmedetomidine and esmolol in attenuation of hemodynamic response to oral endotracheal

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