Wound Injury Essay

6. Effectiveness of amikacin administered by autoinjector compared to manual injection on infected excision wound model of Wistar rats

6.1 Introduction

Injury and wound infection are common in natural and manmade disasters. Serious bacterial wound infections are potential threat to open injuries. These bacterial infections may cause tetanus or gas gangrene which in turn may end up in long term disabilities like chronic wound, bone infection and even death. These infections are of great concern when injured persons present late for definitive care. In disasters, the injured survivors may exceed available trauma care capacity. Timely and appropriate intervention with antibiotic is mandatory to avoid complications and further morbidity and mortality. As accessibility to primary health centre or hospital may not be easy or possible during disasters and thus getting an appropriate expert care and antibiotic support will be a question. So, to overcome such a situation, an antibacterial autoinjector would be useful.

Wound is actually a loss of cellular and functional continuity of living tissues. Wound healing has got different phases in

The wound in untreated group were wet and with malodour linking to infection. There could be a link between malodour and delayed wound healing. Malodour was reduced in treated group which may be due to reduction in microbial presence due to antibiotic therapy and restart of healing. (Kalinski et al, 2005; Jorgensen et al, 2005).

Albumin is a gross indicator for nutritional and fluid status. It is needed for tissue synthesis and fighting against infection. It serves as building blocks of all cells and body tissues along with globulin and total protein. Globulin was slightly increased in autoinjector group but was not significantly high to indicate the superiority of the treatment. Here the infection was not a systemic one to have tremendous