Essomeprazole Lab Report

2003 Words9 Pages
Esomeprazole magnesium trihydrate is a proton pump inhibitor which reduces acid secretion through the inhibition of H+/K+ ATPase in gastric parietal cell. Esomeprazole is the S-isomer of omeprazole. The present study was an attempt made to formulate and evaluate esomeprazole enteric coated matrix pellets by Extrusion and Spheronization method using HPMC, Xanthan gum as control release polymers. Pellets are filled in the enteric coated capsules which were not disintegrated in stimulated gastric fluid. But the first units which disintegrates and produces the minimum effective concentration when the study was continued in phosphate buffer pH 6.8 and further the second units which is prepared by controlled release polymer disintegrated and produce…show more content…
Pre formulation studies were carried out for appropriate selection of excipients in view of Eomeprazole magnesium trihydrate modified release pellets . Angle of repose: Angle of repose is used to determine the flow properties of powders, pellets (or) granules. The accurately weighed powder / pellets were taken in the funnel. The height of the funnel was adjusted in such a way the tip of the funnel just touched the apex of the Powder blend / pellets the powder blend / pellets was allowed to flow through the final freely on to the surface. The diameter of the powder cone was measured and angle of repose was calculated using the following equation . tan =h/r where h and r are the height and radius of the powder cone.

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The pellets were packed in aluminum pouch and charged for accelerated stability study at 40̊ C and 75% RH for 3 months in accelerated stability chamber. At the end of the study the optimized formation was evaluated for drug content and in vitro release profile.

Compatibility studies: In order to investigate the possible interaction between Esomeprazole and distinct polymers FT - IR studies work carried out. FT - IR results proved that the drug was found to be compatible with excipients as wave numbers are almost similar for pure drug.
Evaluation of Preformulation parameters: The Esomeprazole powders / pellets were evaluated for angle of repose, bulk density, tapped density, carr’s index and Hausner’s ratio. From the results of micrometrics studies drug shows good flow property and compressibility property.

In vitro dissolution

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