Essomeprazole Magnesium Trihydrate

Esomeprazole magnesium trihydrate is a proton pump inhibitor which reduces acid secretion through the inhibition of H+/K+ ATPase in gastric parietal cell. Esomeprazole is the S-isomer of omeprazole. The present study was an attempt made to formulate and evaluate esomeprazole enteric coated matrix pellets by Extrusion and Spheronization method using HPMC, Xanthan gum as control release polymers. Pellets are filled in the enteric coated capsules which were not disintegrated in stimulated gastric fluid. But the first units which disintegrates and produces the minimum effective concentration when the study was continued in phosphate buffer pH 6.8 and further the second units which is prepared by controlled release polymer disintegrated and produce

Using the weight of the drug in the cylinder and this minimum volume the tapped density maybe computed.

Tab density = weight of granules / tapped volume of granules Carr’s index: Carr’s index is measured using the values of bulk density and tapped density. The following equation is used to find the carr’s index. Carr’s index = (TD – BD)/TD X 100 where TD = Tapped density

BD = bulk density

Hausner’s ratio Hausner’s ratio is a number that is correlated to the following flowability of a powder (or) granular material. The ratio of tapped density to bulk density of the powders is called the Hausners ratio. It is calculated by the following equation Hausner’s ratio (H) = TD / BD where TD = Tapped density

BD = bulk density

Table 1: Preformulation parameters of powder blend

Parameters F1 F2 F3 F4 F5 F6

Angle of repose (°) 22.01±0.54 26.07±0.37 27.57±0.42 25.24±0.52 28.11±0.91 25.12±0.51

Bulk density (g/cm3) 0.457±0.008 0.56±0.04 0.455±0.005 0.54±0.05 0.44±0.006

in a acidic medium, followed by pH 6.8 phosphate buffer for further 12 hrs.

1 ml of sample was withdrawn after every hour and was replaced by an equal volume of fresh dissolution medium of same pH. Collected samples were analysis spectrophotometer at 301 nm.

Accelerated stability study of the optimized batch: Stability study is used to predict the shelf life of the product by accelerating the rate of decomposition, preferably by increasing the temperature of reaction condition. The pellets were packed in aluminum pouch and charged for accelerated stability study at 40̊ C and 75% RH for 3 months in accelerated stability chamber. At the end of the study the optimized formation was evaluated for drug content and in vitro release