Ethyl Cellulose Research Paper
EXCIPIENTS Ethyl cellulose [Wade A, Weller PJ., 1994] Ethyl cellulose is a derivative of cellulose in which some of the hydroxyl groups on the repeating glucose units are converted into ethyl ether group. • Non proprietary names : Ethyl cellulose Ethyl cellulosum Ethyl-cellulose • Chemical name : Cellulose ethyl ether Aqua coat Surelease • Chemical structure : • Molecular weight : 454.513 g/mol • IUPAC name : 2-[4,5-diethoxy-2-(ethoxymethyl)-6-methoxyoxan-3-yl]oxy-6-(Hydroxymethyl)-5-methoxyoxane-3,4-diol …show more content…
Concentration of ethyl cellulose in various formulations USES CONCENTRATION (%) Microencapsulation 10-20 Sustained release tablet coating 3-20 Tablet coating 1-3 Tablet granulation 1-3 POLYETHYLENE GLYCOL [Wade A, Weller PJ., 1994] Liquid grades (PEG 200–600) which are occur as clear colorless and slightly yellow in color it is colored viscous liquid. It has a slight bitter odor and the burning taste. PEG 600 is present in the solid at an ambient temperature. Solid grades (PEG>1000) it is white or off white in color and range in the consistency from the pastes to waxy flakes. They have a faint sweet odor. PEG 600 and the above are available as a free flowing milled powder. • Nonproprietary Names BP : Macrogols PhEur : Macrogols USP-NF : Polyethylene Glycol • Synonyms : Carbowax, Carbowax Sentry, Lipoxol, Lutrol E, PEG. • Chemical Name : α-Hydro-o-hydroxypoly(oxy-1,2-ethanediyl) • …show more content…
Aqueous solution of the higher molecular weight grades may form the gel. Liquid PEG is soluble in the acetone, alcohol, benzene, glycerin. Solid PEG are soluble in ethanol, dichloromethane. • Stability and Storage Conditions Polyethylene glycols should be stored in well-closed containers in a cool, dry place. Stainless steel, aluminum, glass, or lined steel containers are preferred for the storage of liquid grades • Incompatibilities : Liquid and solid polyethylene glycol grades may be incompatible with some coloring agents. The antibacterial activity of certain antibiotics is reduced in polyethylene glycol bases, particularly that of penicillin and bacitracin. • Safety : Polyethylene glycols are nontoxic and nonirritant materials. Polyethylene glycols administered topically may cause stinging, especially when applied to mucous membranes. • Applications in Pharmaceutical Technology The PEG is water soluble and these are easily removed form the skin by washing which is used as an ointment base for the cream,
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