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Single Etodolac Essay

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STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION OF ETADOLAC BY RP-HPLC Sandhya Rani G 1,Sharon2, Ramesh alli 3 Vaageshwari College of Pharmacy, Thimmapur, Karimnagar Dist.-505481, Andhra Pradesh, India. Corresponding author:sandhyaguggilla9@gmail.com Phone no :8897474898 Abstract: From the literature survey, it was found that there is no stability indicating method for single Etodolac drug but the stability methods are available in combination with other, so there is a need for simple and precise stability indicating method for the drug Etodolac.The proposed HPLC methods are found to have complicated procedure and longer run time so a study was proposed to develop a simple method with lesser run time. The developed method …show more content…

Objective: The proposed HPLC methods are found to have complicated procedure and longer run time so a study was proposed to develop a simple method with lesser run time. The developed method was validated according to ICH guidelines. The different objectives that are to be achieved during development of new analytical and validated stability indicating HPLC method for Etodolac in pharmaceutical dosage form are: • To develop a HPLC method for Etodolac. • To validate the method developed using parameters like accuracy, precision, linearity and range for Etodolac in pharmaceutical dosage form. • To obtain the stress degraded products of Etodolac by different conditions like acid –base hydrolysis, oxidation, photo and thermal stability. • To study the stress degradation behaviour of Etodolac by analysing the different products obtained after degradation using HPLC method. • To apply the stability indicating HPLC method for the Etodolac and degraded products in tablet dosage

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