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Eugenol Case Studies

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Eugenol at the concentrations of 0.2 -20 µm is suggested to be able to produce a dose dependent and reversible vasodilator response that are partially dependent on the endothelium (24). EUG has also found to have a preventive effect on dopamine depression and lipid peroxidation, which can protect depression induced by 6-hydroxyl dopamine (OHDA). Eugenol has prevented depression by decreasing lipid peroxidation and stimulating reduced glutathione (GSH) may lead to a protecting effect (25). TOXICITY of EUGENOL Eugenol is considered safe as a food additive but due to the wide range of different applications and also the extensive use and availability of clove oil; there is a great concern about its toxicity in recent years. Results of a case study indicated that ingestion of 5-10 ml of clove oil to a two-year boy resulted in distressing and crying. After 3 h conditions deteriorated. The acidosis marked and patient was in deep coma. During 8 h, he suffered from a generalized seizure, and within 24 h failure in liver function and also disseminated intravascular coagulopathy (DIC) was noted. Within one week after ingestion and after severe symptomatic …show more content…

In vitro investigations have been done on the genotoxic effects of zinc oxide eugenol and resin based sealers used in dentistry for root canal. Authors have suggested a moderate to severe toxic effects of zinc oxide eugenol in V79 cell line and also demonstrated that these effects are dose dependent suggesting that eugenol has cytotoxic but not genotoxic effects (41). On the other hand the chemopreventive effect of eugenol on DNA damage induced by 7, 12 dimethylbenzanthracene (DMBA) has been evaluated in MCF-7 cells. The observations suggested that eugenol was potent to protect DNA against genotoxic damage induced by DMBA. Eugenol is able to suppress the DMBA activation and acts as a potential chemopreventive compound

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