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Fluconazole And Ivermectin Analysis

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Analytical Method development is the setting up an analytical procedure that will be appropriate for the study of a particular sample and makes the analysis simpler, reliable and easier.(1) Antifungal drug combination with other drug category means antiparasitic, anthelmentic, antibiotics drug etc. So, combination drug used in treatment of infection and infestation. Very few methods reported for estimation of Fluconazole and Ivermectin individually or combination with other drugs. Hence these drugs have been found interesting for analytical research and development. Systematic IUPAC name of Fluconazole 2-(2,4-Difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol The mechanism of action of fluconazole, like that of other imidazole and triazole …show more content…

Ivermectin gift sample from Kamdhenu stermed, Ahmadabad. Double beam UV-VIS spectrophotometer, Shimatzu 1601. Nuforce-plus tablet …show more content…

(ii) ax2ay1 – ax1ay2 Result and Discussion: UV Scan of Ivermectin (IVR) in Methanol:Water UV Scan of Fluconazole (FLUC) in Methanol:Water Overlay Spectrum of Ivermectin and Fluconazole Absorbance values for calibration curve of Ivermectin and Fluconazole Sr. No. Concentration (µg/ml) Absorbance for Ivermectin Concentration (µg/ml) Absorbance for Fluconazole 1. 5 0.205 100 0.223 2. 10 0.395 150 0.328 3. 15 0.598 200 0.442 4. 20 0.778 250 0.571 5. 25 1.004 300 0.669 Calibration Curve for Ivermectin at 245nm Calibration Curve for Fluconazole at 262 nm Linear Regression Analysis of Calibration Curves with Their Respective Absorptivity Values Parameter IVR FLUC λmax (in methanol:water 70:30) 245nm 262 nm Beer’s law limit (µg/ml) 5-25 100-300 Molar Absorptivity (lit/mole/cm) 34903.71 682.41 Regression Equation (Y*) Slope 0.039 0.002 Intercept 0.001 0.007 Coefficient of correlation (r2) 0.998 0.998 Results of Analysis of Tablet Formulation Drug Label Claim (mg) Amount Found (mg) %R.S.D. %Recovery* IVR

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