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Fluoride Research Paper

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ABSTRACT
Background: The aim of present study was to find out the effects of excess of fluoride on ground substance and collagen metabolism and to assess the effects of supplementation of vitamin C, D and calcium on fluoride intoxication. Material and Method: The study was conducted on 100 children of age group 5 to 12 years selected from three fluoride belts of Jaipur district (25 children from each area consuming water with 2.4, 5.6, & 13.6 mg/l of fluoride) compared with 25 controls, consuming water with normal fluoride levels. Drinking water fluoride, serum and urinary fluoride levels were measured by ion selective electrode method. Urinary hydoxyproline, Serum ascorbic acid, Serum calcium, Urinary calcium, Serum sialic acid, Serum hexosamine, Serum inorganic phosphate were estimated by spectrophotometic method. Result: The study …show more content…

effects on bone, teeth, kidneys, thyroid, haematological functions and growth in general and it also increases aging process. Fluoride exposure disturbs synthesis of collagen and leads to its breakdown which is manifested as increase in

excretion of hydroxyproline in urine. Ascorbic acid which is involved in synthesis of collagen was also found to be low in patients suffering from Fluorosis. (3, 4)
Many workers have reported association of disturbed collagen metabolism and low levels of serum ascorbic acid (4).Fluoride toxicity also disturbs the metabolism of amorphous ground substance manifested as altered levels of sialic acid and hexosamine in blood and serum. Fluoride toxicity disturbs calcium homeostasis with concomitant changes in parathyroid hormone which results in causing important changes in bones and other calcified tissues. Combination of calcium, vitamin D and ascorbic acid supplementation could reverse Fluorosis at least in children’s. (5,6)
The present study was therefore planned to correlate:-
1) Biochemical parameters with fluoride in drinking

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