Acrylamide Research Paper
Effects of fried potato chip supplementation on young rats
INTRODUCTION
Acrylamide (ACR) is an alpha, beta-unsaturated vinyl monomer of poly- acrylamide. It is a small organic molecule with a very high water solubility commonly used in industry; mainly as a soil stabilizer. It is also used in coatings, cosmetics, toiletries, food packaging, plastic and aesthetic surgeries as well as in the manufacture of dental fixtures and contact lenses (1). It has several harmful health effects [2–4] and was a major cause of reported occupational poisoning since its use as an industrial material in 1970s [5].
Environmental contamination with ACR results mainly from its use in soil sewer grouting and in waste paper recycling [6]. Cigarette smoke
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) purchased from Sigma Aldrich (ST. Louis, MO, USA). The daily dose of ACR was 30 mg/kg body weight dissolved in 0.5 ml normal saline solution and given by oral gavage for 35 days using sterilized 18 gauge stainless steel feeding needles (Harvard Apparatus, Holliston, MA). The dosing regimen of ACR was based on a study of Seale et al, 2012 (ref. 1) which showed that this regimen resulted in neurotoxicity and growth retardation in young rats.
- Group III (FPC- fed) : this group of rats was maintained on a diet containing approximately 30 % FPC for 35 days. The fried potato chips, purchased from the market, were mixed and grinded with the standard rat food to obtain a homogenized diet
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