Frosta Technology Research Paper

9. Frosta Technology:

This technology patents by Akina. It uses the concept of formulating plastic granules and compressing at low pressure to develop strong tablets with high porosity. Plastic granules are composed of: Porous and plastic material, Water penetration enhancer and binder. The process involves usually mixing the porous plastic material with water penetration enhancer and followed by granulating with binder material. The tablets obtained have better hardness and rapid disintegration time ranging from 15 to 30 s depending on size of tablet.

10. Pharmaburst Technology:

SPI Pharma, New Castle, patents this technology. It utilizes the co-processed excipients to develop ODTs, which dissolves within 30-40 s. This technology involves

Roche friabilator is used to determine the friability by following procedure. A preweighed tablet is placed in the friabilator. Friabilator consist of a plastic chamber that revolves at 25 rpm, dropping the tablets at a distance of 6 inches with each revolution. The tablets are rotated in the friabilator for 4 minutes for 100 revolutions. At the end of test, tablets are reweighed; the loss in the weight of tablet is the measure of friability and is expressed in percentage as;

% Friability = Loss in weight / Initial weight x 100 5)

6 Disintegration Time: The test is carried out using the disintegration apparatus. Phosphate buffer (pH 6.8) maintained at 37ºC ± 2ºC is used as a disintegration media and the time taken for complete disintegration of the tablet with no palpable mass remaining in the apparatus is measured. 7 Wetting Time: A piece of tissue paper folded twice is placed in a small petridish containing 6ml. of distilled water. A tablet is carefully placed on the surface of the paper and the time required for water to reach the upper surface of the tablet is noted as the wetting time. Less is the wetting time, indicates more porous the

Commonly the drugs may have dissolution conditions as in USP monograph. 0.1N HCl, pH 4.5 and pH 6.8 buffers should be used for evaluation of ODT in the same way as their ordinary tablet counterparts. USP 2 paddle apparatus is most suitable and common choice for dissolution test of FDT tablets as compared to USP1 (basket) apparatus due to specific physical properties of tablets. In paddle apparatus the paddle speed of 25-75 rpm is commonly used. Since the dissolution of ODTs is very fast when using USP monograph conditions hence slower paddle speeds may be utilized to obtain a comparative profile. Large tablets (≥1gram) may produce a mound in the dissolution vessel which can be prevented by using higher paddle