Essay On Fungal Infections
INTRODUCTION
Fungal infections are often caused by fungi that are common in environment. The infections are frequently described as opportunistic or primary. They can affect systemically or locally.
Opportunistic fungal infections usually affect people with weakened immune system, for example people with AIDS, as they take advantages of weakened immune system. Typical opportunistic fungal infections include aspergillosis, candidiasis and mucormycosis. They can develop quickly, spreading fast to other part of the body and may lead to death.
Primary fungal infections can affect people with a normal immune system and may cause serious consequences. Most of the primary fungal infections are not aggressive and do not spread to organs deep in the body.
Localized fungal infections affect only one area of the body typically the skin and nails, vagina, mouth, or sinuses. They sometimes occur when the normal balances that keep fungi in check are upset.
The
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Besides, the changes in sterol profile and elevated efflux pump activity reduce its affinity to the drug. Cross resistance between isovuconazole and other triazole antifungal agents can also lead to resistance.
SIDE EFFECTS OF CRESEMBA
Compared with voriconazole, Cresemba was associated with a slightly lower incidence of adverse effects overall and of those requiring discontinuation of therapy. Adverse effects associated with the use of Cresemba may include nausea, vomiting, diarrhea, headache, constipation, hypokalemia, dyspnea, cough, peripheral edema and abnormal liver blood test such as elevations in ALT and AST. It may also cause some serious side effects including liver problems, infusion reactions and severe allergic and skin reactions. Besides, Cresemba may cause fetal harm when administered in pregnant woman.
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