Furosemide Case Study

The three medication I have decided to use is Furosemide, Bumetanide and Torsemide

Loop diuretic act on the sodium, potassium and chloride in the ascending loop of Henle to inhibit the reabsorption. The loop diuretics achieve this by competing with the negative chloride ions binding site. Magnesium and calcium reabsorption in the thick ascending limb is dependent on the positive lumen charged gradient set up by potassium recycling through renal outer medullary potassium channel. Loop diuretics also inhibit their reabsorption. By disrupting the reabsorption of these ions. Loop diuretics also inhibit their reabsorption.

A secondary effect of loop diuretics is to increase the of prostaglandins which results in vasodilation and increased blood

This medication is use both in hospital and long term management of kidney and cardiac pulmonary disease Buck (2009). When used in accepted premotor furosemide is generally well tolerated. Infants that are on long term therapy are particularly susceptible to nephrocalcinoses due to the high calcium execration rate and alkaline urine caused by furosemide Buck (2009)

Elderly population before administration, needs the potassium levels before administration. The general recommendation is that they start on a lower dose. Lab tests when on furosemide can increase blood glucose, blood urea nitrogen, serum amylase, cholesterol, triglycerides and serum electrolytes. Herbal and food can be effect furosemide. Ginseng which is found in many products may decrease the effect of furosemide. The patient needs to be educated about this, and to read the label. Frusemide is used to treat, the same condition as pediatric, cardiac pulmonary and kidney disease. The elderly patient is far more susceptible than their younger counterparts to diuretic-induced hypovolemia which has led to an increased morbidity and mortality in the elderly Adams et al

There is some research that it effects the prostaglandin, which would increase the incidence of patent ductus arteriosus in preterm newborn Cunningham et al (2005) Furosemide has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of fetolethality as well as maternal death at high human doses Schreuder, Bueters. (2016)

Treatment during pregnancy requires close monitoring of fetal growth because of the potential for higher birth weights. In addition, some animal studies demonstrate an increased incidence of hydronephrosis (distention of the renal pelvis and, in some cases, of the ureters) Schreuder, Bueters. (2016)

With the very nature of human pregnancy, it would be unethical to repeat this on human’s subjects and no controlled data exists. Furosemide should only be given during pregnancy when benefit outweighs risk. This is the case in several examples one of which is the treatment of hyperparathyroidism in pregnancy. Furosemide is given in conventional doses to block tubular calcium reabsorption. This well help to bring the levels back to an acceptable range. With any treatment, the benefit and risk need to be explained to the