Gamma Glutamyl Transferase Case Study

Gamma Glutamyl Transferase- A Link Between Oxidative Stress And Periodontitis In Smokeless Tobacco Users And Non Users With Chronic Periodontitis

ABSTRACT

Background:
Long-term usage of tobacco related products are the potential generators of free radicals which alter the cellular antioxidant defense system. Changing the balance towards an increase in the pro-oxidants over the capacity of the antioxidants is defined as oxidative stress (OS), which leads to oxidative damage. Gamma-glutamyl transpeptidase/transferase (GGT), a liver function marker plays a key role in regulating cellular levels of the antioxidant molecule glutathione, hence is a critical enzyme in maintaining cellular redox homeostasis.

Aim:
To investigate and compare the

These include superoxide, hydroxyl (OH), hydroperoxyl, nitric oxide (NO), alkoxy, singlet oxygen, ozone, hypochlorous acid and hydrogen peroxide.6 Under normal physiologic conditions the reactive oxygen species and antioxidants are in an equilibrium. Whenever there is a shift in this delicate equilibrium either by increased ROS release or by its increased activity or by a reduced antioxidant defense mechanism, oxidative stress (OS) results. Oxidative stress was defined by Sies7 as a disturbance in the pro-oxidant–antioxidant balance in favour of the former, leading to potential damage. Therefore if the homeostasis is interrupted in favour of ROS, an oxidative stress situation is