Gasotransmitter Research Paper
1. INTRODUCTION
Gaseous mediators, also known as gasotransmitters, are important signalling molecules which can readily cross the cell membranes, and are endogenously produced. Signalling molecules are involved in the communication of basic cellular activities. Gasotransmitters are easily accessible to specific target molecules which larger mediators are unable to access it. CO and NO are well-known gasotransmitters. Many studies have found that H2S is a new candidate of gasotransmitter (Wang, 2002).
H2S has been shown to be involved in a variety of functions including insulin secretion, kidney function, liver function and many more (Elsey, Fowkes & Baxter, 2010). Also, they are found to have anti-oxidant and anti-inflammatory effects (Locey,
…show more content…
At high concentrations, it can affect the nervous system by preventing cellular respiration, forming complex with iron in the mitochondrial cytochrome enzymes (Locey, 2005). After much research, it is now found to fit the criteria for gasotransmitters, (i) it exists as a gas, (ii) it is permeable to plasma membrane, (iii) it can be synthesised endogenously by enzymes, (iv) it has defined functions at physiological concentrations, and (v) it has specific molecular targets and its effects can be imitated with exogenous applications (Wang, 2002). There have been a lot of evidence documented regarding the therapeutic effects of H2S, mainly in cardiovascular diseases (Elsey, Fowkes & Baxter, 2010).
2.2 Therapeutic effects of H2S
H2S is reported to be a vasorelaxant of blood vessels and its effects seems to involve K+ and Ca2+ channels, though uncertain (Hart, 2011). It has also been found that H2S can produce other hypotensive effects such as regulating plasma renin levels (Lu et al., 2010) and inhibiting angiotensin converting enzyme activity in endothelial cells (Laggner et al., 2007). H2S is also involved in reducing angiotensin II production and inhibiting bradykinin degradation, thus maintaining blood pressure (Laggner et al., 2007).
H2S also plays a role in the regulation of renal function. It increases renal blood flow, glomerular filtration rate and urinary sodium and potassium secretion, hence regulating blood pressure (Hart,
Summary Of This Way For The Gas Ladies And Gentlemen
299 Words | 2 PagesBorowski is very straight forward in the book This way to the gas, ladies and gentlemen because it emphasizes the dark nature of the events that happened in the Nazi concentration camps. In the short story “This Way for the Gas, Ladies and Gentlemen,” Borowski explains how a few people in the concentration camps would get extra food by taking it from the people who were going to be taken to the gas chambers without feeling bad about it. He also details how the infants were sent to their deaths as soon as they reached the concentration camps. Borowski does this because it lets the reader see how indifferent and cruel the S.S. Soldiers were to the people in the camps as well as how numb to the environment the people in the camps became.
Divalproex Case Study
572 Words | 3 PagesIt was also shown that diammonium glycyrrhizinate suppresses Keap1 therefore allowing Nrf2 to protect the hepatic cells from the increase in antioxidants. It also decreased the levels of NF-kappa B in order to decrease inflammation due to the proinflammatory
Scuppernong Research Paper
882 Words | 4 PagesThis ensures smooth blood flow throughout the body. It further balances out the undesirable effects of excess sodium and supports good kidney function. Lowers high blood cholesterol
Gasmask Research Paper
451 Words | 2 PagesWhy did you go after to find Sasha? I went after to find Sasha because she is my true love. Also, I went after to find her because when we were in the infected zone together she saved my life, when the jocks were after me. Sasha also saved my life by helping me into a gang so I had a place to stay and food to eat. Were you ever scared looking for Sasha in the infected zone?
Summary Of This Way For The Gas Ladies And Gentlemen
863 Words | 4 PagesThis Way for the Gas, Ladies and Gentlemen is a story written by Polish writer and journalist Tadeusz Borowski. He grew in an era of war which he had to maneuver to survive. The story reflects what he had to go through when he was imprisoned in the most infamous Nazi concentration camp in World War II: Auschwitz-Birkenau. He explains with vivid details his experiences without deepening into obvious moral judgments of his own or other inmate actions and just recounts what he saw and had to do to survive.
Liver Disease Case Studies
2101 Words | 9 Pages1. Introduction Liver disease represents a considerable public health burden that involves several etiologies overlapping symptoms (El-Serag & Rudolph, 2007). Since the seventies, the experimental model of carbon tetrachloride (CCl4) hepatotoxicity have been closely studied using in vivo models of acute and chronic liver injury. This process has been used comprehensively to examine the pathogenesis of liver injury such as centrilobular steatosis, inflammation, apoptosis and necrosis. CCl4 deteriorates hepatocytes directly by altering the permeability of the plasma, lysosomal, and mitochondrial membranes through initiation of lipid peroxidation with trichloromethyl radical (CCl3•) or trichloroperoxyl radical (CCl3OO•) by the hepatic microsomal cytochrome P450 oxygenase system.
Est1 Task 2
1664 Words | 7 PagesSeveral other functions that it plays in the body include: balancing the electrolytes in our system, maintaining the acid-base balance and is significantly essential to muscle contraction and nerve transmissions throughout our body. A deficiency in sodium can put individuals at risk for contracting hyponatremia which is a dangerous condition in which an individual has too little sodium in their blood. The connection between sodium and water is directly correlated in keeping an equal ration of sodium and water in the body. For example, when the body contains too much salt, the body responds in keeping homeostasis by telling the individual to drink excessive water – polydipsia- until there is an equal balanced ratio of sodium to water. In addition, individuals who consume more than the recommended intake of salt tend to show signs of excessive weight gain, but in reality is just a side effect water weight in the body for this its way of maintaining a balance ratio until the salts are expelled from the body.
Treblinka Gas Chamber Analysis
1033 Words | 5 PagesIn the poem “Treblinka Gas Chamber”, by Phyllis Webb and in the TRC’s “The History”, both texts share a common theme of inhumane treatment towards children within certain cultural and ethnical groups. While the two authors explore distinct historical contexts, both texts are centred on racial segregation with nationalistic motives. Phyllis Webb appeals to a logos strategy through the use of allusion. In her poem, “Treblinka Gas Chamber”, Webb presents fictional and historical examples to display her knowledge and establish her credibility.
Tritace Case Study
1281 Words | 6 PagesRenin converts angiotensinogen to angiotensin I. Angiotensin-Converting-Enzyme which is found in pulmonary blood vessels, acts on angiotensin I to convert it to angiotensin II. Angiotensin II activates angiotensin receptors AT1 and AT2. The result of the activation of AT1 is vasoconstriction and secretion of aldosterone (Brenner et al, 2003). Aldosterone secretion results in fluid retention
Lactose And Glucose Lab Report
285 Words | 2 PagesAs illustrated in Figure 1 and 2, the volume of gas collected for both glucose and maltose produced similar carbon dioxide at a rapid pace of 0.5 min. The results indicate that there is no significant difference between the metabolic rate of glucose and maltose, due to its incubation time. However, the trials for lactose showed no signs of gas production. As shown in Figure 4, glucose had produced the most gas per minute with an average respiration rate of 6.4 mL/min, while lactose produced a negligible amount of gas of 2.6 mL/min, compared to maltose with an average respiration rate of 5.2 mL/min.
Gas Powered Car Research Paper
608 Words | 3 PagesPeople that drive gas-powered cars get scammed by mechanics. Mechanics charge ridiculous prices for a fairly simple process. They can also cause other problems with the car, so you will continue to finance their company. Mechanics scam customers for an oil change, but individuals can conquer being overcharged by sticking to these painless procedures. First the following supplies are essential to successfully accomplish this task.
Essay On Carburetor
962 Words | 4 PagesThe basic principle of the most vehicles on either in land, air or water is mixing fuel and air. Cars, trucks, jet engines, and motorcycles mixed fuel and air to become power and burn in cylinders inside the engine. The amount of fuel and air that enters the engine varies from time to time, depending on the time running, speed, and other factors. However, modern vehicles use and electronic devices to control the amount of air and fuel that enters the system called fuel injection Carburetor was invented by an Italian, Luigi de Cristoris on 1876. After a few years, Karl Benz made his own carburettor when he developed the first automobile run by internal combustion.
Gas Backpack Leaf Blower Research Paper
845 Words | 4 PagesThese are the best backpack leaf blowers you need – we incorporated each spending extent, and you have to settle on your choice in light of how tons you will spend. They're the most acclaimed and go to answers for his or her rate assortment. Consequently, it ought to be a straight-forward decision in light of how a great deal of money you have. Husqvarna 150BT 50.2cc 2-Cycle Gas Backpack
Vitamin B Research Paper
735 Words | 3 PagesVitamin B1 Thiamine Although Vitamin B, was one of the first vitamins ever recognised, known for thousands of years. It was not until the late nineteenth and early twentieth century that it was recognised as having a dietary role. In the Far East consumption of “polished” or refined rice often led to Vitamin B1deficiency.
Endurance Exercise Analysis
1675 Words | 7 Pagesal., 2001) which also plays a role against irregular heartbeat (Hamilton, Quindry, French, Staib, Hughes, Mehta, Powers,
More about Gasotransmitter Research Paper
Summary Of This Way For The Gas Ladies And Gentlemen
299 Words | 2 PagesDivalproex Case Study
572 Words | 3 PagesScuppernong Research Paper
882 Words | 4 PagesGasmask Research Paper
451 Words | 2 PagesSummary Of This Way For The Gas Ladies And Gentlemen
863 Words | 4 PagesLiver Disease Case Studies
2101 Words | 9 PagesEst1 Task 2
1664 Words | 7 PagesTreblinka Gas Chamber Analysis
1033 Words | 5 PagesTritace Case Study
1281 Words | 6 PagesLactose And Glucose Lab Report
285 Words | 2 PagesGas Powered Car Research Paper
608 Words | 3 PagesEssay On Carburetor
962 Words | 4 PagesGas Backpack Leaf Blower Research Paper
845 Words | 4 PagesVitamin B Research Paper
735 Words | 3 PagesEndurance Exercise Analysis
1675 Words | 7 Pages