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Mendel's Human Genetics

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Summary - Mendel and Human Genetics

Mendel 's laws of genetic inheritance initiated an era of genetics which feeds on the complete functional information of each and every ' 'modern ' ' gene of the organisms.
Mendel 's studies; instead of being able to reach human genetics directly through his observations, eventually made it 's way to human genetics through the basic rules of genetics that Mendel deduced while working on Pisum sativum. With the advancement of technology and uprising of brilliant minds, the chromosome had its shape defined, along with its behavior deduced during cell division and gametogenesis. All these observations and a formulation for heredity by Weismann led to a need of laws by which characters transfers from parent …show more content…

Later, Yule 's work in 1902 showed that the Mendelian F2 ratio 1:2:1 for monohybrid cross, stays conserved throughout the generations when the mating between all individuals is random, also that dominant alleles shows an increase in the population. The latter was argued by Castle in 1903, stating that once the selection discontinues the genotype frequency shows stability.
On the basis of Yule 's and Castle 's findings, Punnett with the help of G. H. Hardy deduced a formula which described the constancy of genotype in generations; pr=q. This, later-on became the Hardy-Weinberg law (m^2*AA + 2 m*n AB + n^2*BB, A and B are alleles), when similar observations of Weinberg were found.

Environmental effect on the gene expression had been observed since the time of Mendel. Mendel observed the environmental effects on gene expression with the flowering time-periods of the pea plants. Later, Muller in 1925 along with Barbara Burks tried to study environmental effects on the mental attributes of twins (identical and non-identical) on which initially two medical practitioners Siemens and von Verschuer were

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