Genetic Disorders: Haemophilia

Although half of your chromosomes come from your mother and half from your father, your genetic pattern can be different from the patterns of either of your parents. Your genes determine who you are, for example they determine your

Later it was discovered that it was the result of an extra copy of chromosome 21. The nondisjunction that results in an extra copy of chromosome 21 occurs during anaphase I in meiosis I. The genetic mutation is trisomy 21 (3 copies of chromosome 21). The characteristic phenotypic occurrences that are distinct to the disorder: poor muscle tone, stout neck, flat face, small head, mouth, and ears, eyes slanting upwardly, Brushfield spots, and stout fingers and

Is it possible for a boy-girl pair of twins to be genetically identical? Why or why not? No, it is not possible for a boy-girl pair of twins to be genetically identical. This is impossible because females have two X chromosomes, and males have one X chromosome and one Y chromosome.

Women have two X-chromosomes so that is why they will not have the disease. They have one defected gene and one normal. Their normal

The purpose of this essay is to determine whether it was an appropriate decision to strip Jonathan Jackson of his job because of his genetic disorder, Haemophilia. They believe that Jonathan Jackson will be unable to function in his role as an air traffic controller. It will also investigate whether their employers should be given the right to make decisions based on their medical information from their DNA and then make this information available to other future employers. Haemophilia is a rare bleeding disorder in which the blood doesn 't clot normally. If someone has haemophilia, they may bleed for a longer time than others after an injury.

Explain. A. polydactyly is actually a autosomal dominate trait & not sex linked. Q. what specifically caused this disorder? A. what causes polydactyly are genetic defect or underlying hereditary syndrome. Its actually the gene that is responsible for it is GLI3 its what genes work and which ones don’t.

Cystic Fibrosis is a serious genetic disorder that affects the insides of a human body. Cystic Fibrosis is a genetic condition in which the lungs and the insides of the human body become clogged with thick sticky mucus. The mucus builds up inside of the body and affects the insides like the lungs, liver , pancreas, your sinuses, and more. Cystic Fibrosis also affects the digestive system which makes food harder and a longer time to digest. Some symptoms for cystic fibrosis are salty-tasting skin(sweat), poor growth, and poor weight gain despite normal food intake.

From that, we know the gene is on an autosome, which is a non-sex chromosome. The word recessive tells us that the individual has to be a homozygous recessive, with two copies of the gene, to express the trait or disorder. One is inherited from the mother, and one from the father. Carriers, individuals who only have one recessive gene, are not affected by the disease but are able to pass it down to their children. Most people are not aware they carry a recessive gene for a disease until they have a child with the disease.

Sickle cell anemia is a genetic disorder it is also known as sickle cell disease. A genetic disorder is something that is passed down from parent to child. This is a disease of the hemoglobin. Hemoglobin is a red protein responsible for transporting oxygen in the blood of vertebrates. Sickle cell anemia causes your red blood cells to stiffen, although your red blood cell are supposed to be flexible.

An example of a chromosomal disorder is down

• Two haploid daughter cells are formed o Sister chromatids separate in meiosis ll • Second division that separates sister chromatids • Chromatids may not be identical due to crossing over in prophase I • Chiasmata formation between non-sister chromatids results in the exchange of alleles o Crossing over is the exchange of DNA material between non-sister homologous chromatids • When chiasmata is formed between the bivalents in prophase I, DNA is exchanged between the non-sister homologous chromatids • Crossing over results in production of new allele combination on the chromosomes • Recombinant chromosomes consist of genetic material from both homologues o Crossing over produces new combinations of alleles on the chromosomes of the haploid cells • Genes may be linked or unlinked and are inherited accordingly o Gene loci are said to be linked if on the same chromosome / • Linkage group is a group of genes whose loci are on the same chromosomes and don't independently assort • Linked genes tend to be inherited together • Don't follow the normal dihybrid cross • Phenotypic ratio is more closely assigned to monohybrid cross as two genes are inherited in a single unit • Linked genes may become separated through

Hemophilia - the hereditary lack of a blood clotting factor typically caused by a recessive X-linked genetic mutation - has been at the forefront of public attention for centuries due in part to its seemingly mysterious presentation almost exclusively in males and its prevalence among European and Russian royal dynasties due to inbreeding - but has only been the subject of serious medical study and treatment for the past two centuries. “Before the modern era, there was some recognition of the experience of familial bleeding… but there was still no formal knowledge of hemophilia within medical circles, still no pathology,” writes historian Stephen Pemberton in The Bleeding Disease (21). The first writing referencing hemophilia is a Jewish

Klinefelter syndrome, also known as ‘47,XXY’ and ‘XXY’ is found in males, this is due to the fact that the host male gets another X chromosome. The image on the right you can see the extra chromosome with the pair of sex chromosomes. Usually there are only two chromosomes that determine the sex, one from opposite sexes but when it comes to Klinefelters Syndrome there is an extra X chromosome. Because this due to the additional chromosome it can described as a chromosome disorder.

This means since my father’s earlobes are attached, differing from my mom’s free hanging ones, one of them has a homozygous recessive genotype. Due to the fact my brother and I both have free hanging earlobes like my mother, the probability is higher that free hanging earlobes are a dominant trait. For example, if my mom’s trait was heterozygous, meaning her phenotype would still be that of a dominant one, the probability my parents have a child with free earlobes is 50% along with the chance of having a child with attached at also 50 %. If my mom carried the homozygous dominant alleles instead of the heterozygous, the probability my parent’s offspring would have free hanging earlobes would be

Haemostasis is a physiological process of blood clotting and dissolution of the clot, followed by the repair of injured tissue. It results from interplay of vascular endothelium, platelets, coagulation factors, anti-coagulation mechanisms and fibrinolytic system. The fluidity of blood in the absence of injury is maintained by the balance between pro-coagulant pathway, and the mechanisms that inhibit the pro-coagulant pathway. Imbalance between the two mechanisms, for example during clinical illnesses or preoperative period, predisposes a patient to either bleeding or thrombosis. To stop bleeding after injury, a complex process is initiated within seconds.