Genomic Imprinting Thesis
Morgan Bundy
Gust - 8B My Thesis On Equine Genetics
13 Dec. 2017 Equine Genetics is a vast and complicated topic. I find it fascinating to read of all this new and up-to-date technology we have to aid in our understanding of the Equine. One topic in the “Next-generation sequencing” (pg. 6 / p. 2) [4] section has caught my attention in particular, and that would be the role of the horse placenta in genomic imprinting. The definition of genomic imprinting (in my words, of course,) would be this: When a gene conveys an imprinted allele from one parent, it is muted and the allele from the other parent, only, is seen. For instance, if an allele from the father is imprinted, it is “silenced” (p. 7) [1] and the allele from the mother is solely shown, and vice versa. That being said, the unseen allele is still there, just not prominent.
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Apparently, Equines are the only genus that has this particular feature [1]. According to a study done by Cornell Research, it is said, “Though placentas support the fetus and mother, it turns out that the organ grows according to blueprints from dad…” and “...the genes in a fetus that come from the father dominate in building the fetal side of the placenta.” (p. 1) [2] So it seems that the placenta not only allows “...the metabolic exchange of the the nutrients, oxygen and waste material.” (pg. 1 / p. 1) [3] between dam and foal, but it is also a home for genomically imprinted genes. The Equine placenta is an undeniably imperative factor in the development of imprinted
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