Black Tea Vs Green Tea
Camellia sinensis, is a plant which leaves are used to make green tea or black tea. The difference between green tea and black tea is that oxidation process does not take place in the production of green tea. Due to the lack of steaming process, green tea is found to have a relatively high polyphenol content compared with black tea (18). These polyphenols consist of a number of phenolic rings and EGCG is known as the most abundant (nearly 40% of the total polyphenol content) and the most active chemical component which belongs to this family. According to studies, polyphenols are powerful antioxidants and cancer chemopreventive (15). They play a role in neutralizing free radicals, reduce inflammation and slow down the growth of tumour.
2.2 Pharmacological
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Plaque which is usually made of fatty substances (cholesterol, triglycerides, lipoprotein etc.) is the main culprit that cause atherosclerosis, and it can partially or completely block the blood flow in the arteries. Stages of plaque development including fatty streak, plaque progression and plaque disruption. Risk factors of atherosclerosis that could be modified including dyslipidemia, smoking, hypertension, and diabetes mellitus (DM). These factors can directly or indirectly promote the development of atherosclerotic lesion for example dyslipidemia causes the accumulation of low density lipoprotein (LDL) in the arteries and hypertension enhances the retention of LDL by modifying the vessel wall. LDL may also undergo some chemical modifications such as oxidation and glycation through smoking and diabetes mellitus factor. However, there are some risk factors for instance older age, male gender and family history of coronary heart disease are not modifiable …show more content…
The approach is based on the size reduction of drug compounds to nanosize in order to alter their physical properties (27). Zhang et al. synthesized (-)-EGCG encapsulated nanostructured lipid carriers and chitosan-coated NLCE using natural lipids, surfactant, chitosan, and EGCG. These nanoformulations were found to have ability to inhibit the development of atherosclerotic lesion by reducing macrophage cholesterol content as well as the expression of MCP-1
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