Grignard Reagent Lab Report

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The purpose of this experiment was to synthesize a Grignard reagent with 1-bromobutane and homogenized magnesium in anhydrous diethyl ether. This solution was refluxed in a flask connected to condenser and drying tube. As seen in the mechanism, maintaining a dry condition is important to avoid the Grignard reagent from attacking water, which will result in loss of the bromine. It is important to reduce the amount of moisture and water vapors to avoid destroying the Grignard reagent, which is essential to the synthesis of 2-methylhexanol. Hence, a calcium chloride and cotton were filled inside a drying tube. The condenser was wrapped with parafilm and a paper towel to avoid moistures from entering. The reagent will act as nucleophilic addition to acetone and work up with hydrochloride acid to synthesize 2-methylhexanol. Throughout this process, the solution turns dark grey and develop white precipitates. This step indicate that Grignard reagent was generated, and the extra white precipitates were magnesium. The addition of hydrochloride acid and cooling the flask contain the solution in an ice bath formed a clear solution. This solution was transferred to a separatory funnel and added with diethyl ether to form two layers: organic and aqueous. The organic layer was extracted by distillation of the aqueous layer first. Diethyl ether was used for rinsing. Finally, potassium carbonate was used as a drying agent, and the organic layer was extracted to be concentrated in

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