Benzyne Formation and the Diels-Alder Reaction Preparation of 1,2,3,4 Tetraphenylnaphthalene Aubree Edwards Purpose: 1,2,3,4-tetraphenylnaphthalene is prepared by first producing benzyne via the unstable diazonium salt. Then tetraphenylcyclopentadienone and benzyne undergo a diels-alder reaction to create 1,2,3,4-tetraphenylnaphthalene. Reactions: Procedure: The reaction mixture was created. Tetraphenylcyclopentadienone (0.1197g, 0.3113 mmol) a black solid powder, anthranilic acid ( 0.0482g, 0.3516 mmol) a yellowish sand, and 1,2-dimethoxyethane (1.2 ml) was added to a 5-ml conical vial.
In this experiment, it was possible to produce the major products from bromination of acetanilide and aniline. 0.075g of 4-bromoacetanilide and 0.156g of 2,4,6-tribromoanilne were collected from bromination of 0.07g acetanilide and 0.05g aniline with the percent yield of 67.57% and 88.1% respectively. At the end of the experiment, to prove the formation of the major products, melting point of the products were measured. The melting point of the product from the bromination of acetanilide was 164.8-168.50c, which is in the range of the melting point of 4-bromoacetanilide, 165-1690c, as reported on the Chemical Book, CAS Database List (chemicalbook.com). The melting point of the product from the bromination of aniline was 119.8-121.90c, which is in the range of the melting point of 2,4,6-tribromoaniline, 120-1220c, as indicated on PubChem, Open Chemistry Database (pubchem.ncbi.nlm.nih.gov).
The triphenylmethyl methyl ether is almost pure with only a 0.05 difference in Rf values. Introduction The purpose of this experiment is to create an organic compound by a SN1 reaction. The starting material is triphenylmethyl chloride which reacts with methanol to produce an ether. Methanol is the solvent and nucleophile of the reaction.
Bromination is the process where an alkene is halogenated with bromine. The purpose of this experiment was bromination of stilbene to stilbene dibromide. The element bromine is toxic and requires maximum care when used. Bromine was generated in the reaction mixture by using a green method. Less hazardous reagents were used to do so.
In this experiment, Analysis of Gaseous Products, a comparison between the elimination reactions created in the presence of an acidic and basic conditions was observed to be further analyzed through gas-liquid chromatography. These conditions were achieved by acid-catalyzed dehydration of a secondary and primary alcohol and based-induced dehydration of a secondary and primary bromide. As a result of these changing eliminations, gas-liquid chromatography makes it possible to separate and isolate volatile organic compounds to analyze the stereochemistry and regiochemistry of these compounds without decomposing them. Overall, gas-liquid chromatography of these compounds in acidic or basic conditions contributed in the identification and analysis
1. Cocaine became popular when it started being used for more and more things as its uses became more and more known. Cocaine use originated around 5000 BECAUSE with the Incans of Peru. Cocaine was used as a stimulant to help the natives get through grueling, long, active days of work. As time went on the plant became an integral part of their lives; used as money, an herb and during religious ceremonies.
Nevertheless, the latter is not used in this experiment since it is very reactive and extremely flammable. On the contrary, NaBH4 is relatively mild and it can be used with protic solvents. In this manner, 1.507 grs of the ketone 9-fluorenone were mixed with 30.0 ml of 95% ethanol in a 125 ml Erlenmeyer flask. The bright yellow mixture was stirred during 7 minutes until all the components were dissolved.
It is understood the mechanism is acid-catalyzed where protons coordinate with the carbonyl oxygen to make the carbonyl carbon more electropositive for nucleophilic attack (Scheme 1). In the experimental procedure all reactants were added together, this is inefficient as the protons can coordinate with either trans-cinnamic acid or methanol. Coordination with methanol is unnecessary as it reduces its nucleophilicity and makes less protons available to coordinate with the carboxylic acid. To improve
Experiment 2 Report Scaffold (Substitution Reactions, Purification, and Identification) Purpose/Introduction 1. A Sn2 reaction was conducted; this involved benzyl bromide, sodium hydroxide, an unknown compound and ethanol through reflux technique, mel-temp recordings, recrystallization, and analysis of TLC plates. 2. There was one unknown compound in the reaction that was later discovered after a series of techniques described above.
The reaction to synthesize benzocaine was known as a Fisher esterification reaction. The Fisher esterification was reaction between alcohol and carboxylic acid in the presence of acid. The reaction was used to form an ester. In the experiment, sulfuric acid acted as a catalyst and necessary for this reaction to occur. There was a change between the –OH group of carboxylic acid to an –OCH2CH3 group in the reaction.
PALLADIUM-CATALYZED CROSS COUPLING REACTION IN ORGANIC SYNTHESIS The formation of new carbon-carbon bonds is of central importance in organic chemistry and a prerequisite for all life on earth. Through the assembly of carbon atoms into chains, complex molecules, e.g. molecules of life, can be created. The importance of the synthesis of carbon-carbon bonds is reflected by the fact that Nobel Prizes in Chemistry have been given to this area many times: the Grignard reaction (1912), the Diels-Alder reaction (1950), the Wittig reaction (1979), and olefin metathesis to Y. Chauvin, R. H. Grubbs, and R. R. Schrock (2005) and Richard F. Heck , Ei-ichi Negishi, Akira Suzuki (2010) for the development of methods for palladium-catalyzed formation of carbon-carbon
The Hydrolysis reaction included an acidic environment and an acidic catalyst to make the reaction occur faster and initiate the reaction as well. The acidic environment is required in order to add the hydrogen and oxygen onto the carbonyl groups in the final product. Dicarboxylic acid is not very soluble in water/acetone which ultimately resulted in larger yield of product. 2.
Chemistry IA Background information: Introduction: Electrolysis it’s a chemical process that when you pass an electric current into a solution or a liquid that contains ions to separate substances back to their original form. The main components that are required for electrolysis to take a place are: Electrolyte: it’s a substance that when dissolved in water it ionize and then it will contain free moving ions and without these moving ions the process of electrolysis won’t take place. Direct current (DC): This current provides the energy needed to discharge the ions in the electrolyte Electrodes: it’s an object that conducts electricity and it’s used in electrolysis as a bridge between the solution and power supply. A great example