A review of Helicobacter pylori causing gastritis and treatment
Abstract
Helicobacter pylori infection causes lifelong chronic gastritis, which can lead to peptic ulcer, mucosa-associated lymphoid tissue (MALT) lymphoma and gastric cancer. The growing problem of antibiotic resistance by the organism demands the search for novel candidates from plant-based sources. H. pylori infection is associated with a decreased risk of some other cancers, including gastric cardia cancer (cancer in the top portion of the stomach) and esophageal adenocarcinoma. However, these therapies have several inherent problems, including the appearance of resistance to the antibiotics used and associated adverse effects, the risk of re infection and the high cost of
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This review summarises the most relevant recent studies on vaccine and plant based development and new treatments using natural resources such as plants, probiotics and nutraceuticals. In addition, novel alternatives based on microorganisms, peptides, polysaccharides, and intragastric violet light irradiation are presented. Alternative therapies have not been effective in eradicating the bacteria but have been shown to maintain low bacterial levels.
Keywords: Helicobacter pylori; Treatment; Natural products; Probiotics; Nutraceuticals
1. Introduction Gastric cancer was once considered a single entity. Now scientists divide this cancer into two main classes: gastric cardia cancer (cancer of the top inch of the stomach, where it meets the esophagus) and non-cardia gastric cancer (cancer in all other areas of the stomach), Infection with H. pylori is the primary identified cause of gastric cancer. H. pylori is a perhaps one of the most common human infectious agents worldwide. Genetic sequence analysis has indicated that human being has coevolved with H. pylori for more than 58,000 years (Linz et al 2007) worldwide gastric cancer is the second leading cause of cancer-related infection
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The impact of H. pylori infection on gastric malignancies may depend on the anatomic location. Cancers of the proximal stomach (cardia and gastroesophageal junction) have different epidemiological and pathophysiological characteristics and are not commonly found in high H. pylori endemic areas (Kamangar et al 2006). For example, adenocarcinoma derived from gastroesophageal junction may be associated with neither H. pylori infection nor Barrett’s esophagus (Kamada et al
Identification of bacteria within Unknown Culture #21 In this experiment, an unknown culture of two different types of bacteria was assigned to each person, a number of tests were performed to isolate and identify these bacterial cells. Based on knowledge from the previous experiments completed in lab, a basic understanding of each type of bacteria was used to create a flow chart that would aid the process of identifying the unknown bacteria within the culture. A gram stain that is performed initially will narrow down the types of tests certain bacteria will and will not respond to. In addition to the gram stain, some of the tests that were used include, a catalase test, an Eosin methylene blue (EMB) agar test, a bile esculin test, and a 6.5% sodium chloride (NaCl) test.
In week 5, the patient reported feeling well again. However, looking at the bacteria in the gut during week 5 there is a lot of empty space. This shows that the antibiotics killed not only the bad bacteria, but a lot of the good bacteria also. This is not a good way to treat infection because when the body could develop a new infection, there would not be enough bacteria to kill off the bad bacteria. During week 7, the patient reports feeling sick again.
Healthcare professionals must talk to their patients about possible side-effects of drugs they are taking and make sure they understand what can happen. In doing so, patients may start to understand why something is happening to them and it is a normal side-effect, which can not only lead to trust from the patients to providers, but can lead to the passing of knowledge from one to another which may prevent future
In 1981,Barry Marshall had a theory for the cause of duodenal and gastric ulcers. Scientist didn 't believed him, so he decided to drink a bacterial cocktail to prove his theory was right. Although, he became very sick and severed from nausea, Marshall took an endoscopy which revealed inflammatory signs of gastritis and the presence of H. pylori. Marshall results proved that H.
Crohn and his two co-workers, Oppenheimer and Ginzburg, presented a paper on “Terminal Ileitis”, and it was described in the features of Crohn’s disease to the JAMA. It was published later that year as a landmark article in the Journal of the American Medical Association aka “JAMA” and with the title “Regional Ileitis: A Pathologic and Chronic Entity.” The JAMA article was published at a time
Fear can cause some patients to feel “ treated as mere "experimental model(s)" for the studies, while others refuse to take part because of historical evidences of clinical trial fraud and misconducts known to them” (Nijhawan 134). Preconceived patient perceptions lead patients to “believe that, trials will put extra burden on them. They assume that the conventional treatment is best and they are afraid of the unknown side-effects of new treatment. Convincing and receiving an informed consent from such patient is most difficult. In some case disclosing too much information of the potential side-effects may unnecessarily scare the patient away from a potentially life-saving or life-enhancing surgery or procedure”(Nijhawan 134).
A considerable number of people believe that the diagnosis and treatment of health problems are beneficial to improving and maintaining overall health, but too much dismay, there are also potential harmful affects with this type of medical practice (Martin, 2017). The practice of overtreatment and overdiagnosis is a prominent issue within the healthcare system. One of the main reasons that healthcare providers and their patients feel the need to treat and diagnose each health problem, big or small is that society has a compulsion to cure. Healthcare providers conform to the idea of compulsion to cure because amongst other reasons, they fear litigation and disappointing patients if they choose against conducting tests in order to diagnose and
According to the Mayo Clinic staff (2014), chronic inflammation can create ulcers in the digestive system, located anywhere from the mouth to the anus, and also the genital area. Inflammation to the lining of the stomach, can lead to scars that can spread throughout the bowel wall completely. Mayo Clinic Staff (2014) state that Crohn’s causes the intestinal wall to become thickened as time goes by, which prevents food from digesting properly due to blockage making it hard for stools to pass by. Mucosa is what protects the stomach, by having Crohn’s, excess mucous is being produced which can make an individual feel as if they are always needing to go to the bathroom.
The more traditional framework that would have been used would have been the scientific biomedical framework. This framework is a model that does not take into consideration the psychological and social factors which may be contributing to a person’s illness; the illness is simply seen in biological terms. This ideology is far outdated, and one can see this simply by reading the WHO’s most recent definition of health, mentioned in the opening of this paper. This model views medications as the resolution to all illnesses, however we know that in today’s society, medications can often cause further problems- for example the creation of superbugs such as MRSA in the hospital system, bugs that as a result of overexposure to antibiotics have now become immune to the medication’s effects, and can therefore be detrimental to a patient’s health. By choosing to concentrate merely on biological impacts on health, a vast array of other factors, such as the environment, the money invested in public health care systems and many more, are ignored.
Patients often do not receive adequate education or instruction when they are prescribed a new medication3. This can lead to the patient being confused about the medication and being uncomfortable with taking it. One other issue regarding communication are the possibilities of alternatives. Alternatives could be a cheaper version of the drug or just a different dosage form. Patients should always be given an adequate opportunity to discuss alternatives and concerns about a new medication with their provider.
Crohn’s disease is most prevalent in developed countries like the United States, the United Kingdom, Australia, New Zealand and Scandinavia. The occurrence of this disease is less in developing regions of the world due to the root causes - mainly genetic and being triggered by food habits (more dependence on animal protein in developed countries while in less developed countries a lot more animal protein is consumed) and environmental reasons. Crohn’s disease has been a major problem since the beginning of World War 2 when it was first discovered. The disease has claimed the lives of over two hundred thousand Americans, and has infected almost 1.6 million since 1943. The number of people who have been diagnosed with this disease has increased
However, the physicians did not reveal the actual purpose of the study. Consequently, penicillin was the most effective medication, but the doctors decided to withhold treatment (Bozeman, Hirsch, & Slade ,
However, half considered to be potentially preventable (Caughey et al., 2014). Dr Roughead, who from Quality Use of Medicines and Pharmacy Research Centre, University of South Australia, use his experiment to express different kind of medication-related problems commonly happened in Australian patient and the percentage of each problem. (Show as table
The problem starts with prescribing these drugs in the first place, and the most logical explanation is to decrease the rate at which we are prescribing them, or to stop
Inflammatory conditions of the intestinal tract such as Ulcerative colitis or Crohn’s disease which can lead to chronic