Patient’s laboratory findings were ; creatinin: 1.02 mg/dl, albumin: 2.9 mg/dl, Total bilurubin: 4.0 mg/dl, ALT:22 IU/L AST:20 IU/L, hemoglobin:10.6 gr/dl, platelet: 232.000, protrombin time: 18.7 sn, INR: 1.37, serum protein elektrophoresis: beta-gamma bridging, serum-ascites albumin gradient: 2.1 gr/dl, AFP: 6000 IU/ml, CA 19.9-CA 125-CEA: negatif, HBsAg (+), HBeAg (-), HBV DNA: 61.700 IU/ml, HDV (-), AntiHCV (-), markers for otoimmun hepatites and other etiological tests were negative. The patient was diagnosed as chronic dekompansated liver parenchymal disease due to ethanol taking and chronic heatitis B (HBV) infection. His Child-Pugh score was 9.0 (B) and MELD score was 15. He had not hepatic encephalophaty and spontaneous bacterial peritonitis infection. Stage 2 oesophageal varices were present at his gastroscopic study.
Summary: Prior to starting my research, I had a very rudimentary understanding of IPF. As I look at my research I am able to connect some of the pathophysiology to the tests that are usually performed for diagnosis. For example, the increase scarring and deposition of fibrotic tissue in the lung is seen as reticulonodular opacities on a chest x-ray. Additionally, the spirometry test results are consistent with my understanding of restrictive diseases and their effects on FEV1 and FVC. As far as the treatments go, Pirfenidone is an anti-fibrotic agent that inhibits collagen synthesis and slows the progression of the disease by reducing the amount of connective tissue deposition in the lungs.
In addition, the IACUC cannot actually prevent the laboratories from causing suffering in animal experimentation if the scientist deems the experiment as a scientific need. This means that if the experimenters claim that the use of procedures that subject laboratory animals to pain and distress is necessary to further human health, then the IACUC will approve the experiment. This is a problem that needs to be fixed because it allows scientific experimenters to conduct any procedure that will cause suffering to the animals. This needs to change because these committees do not protect the animals, it is only a weak barrier to lessen animal suffering (Rowan).
The patient had been previously operated 3 months back for sub-occipital craniotomy with a right sided ventriculoperitoneal (VP) shunt prior to the definitive surgery. Tumour marker studies showed a high level of MIB1 (an antibody against a protein called Ki-67, expressed in proliferating cells) of 35%. Examination revealed the patient was febrile but conscious and oriented with normal movements of all 4 limbs but a positive kerning’s sign. The hematological investigations showed leucocytosis (count of 15,700) and cerebrospinal fluid examination was consistent with the picture of bacterial meningitis. Intravenous antibiotics vancomycin and meropenem were started after verifying renal status.
Antibiotics tested included: gentamicin, teicoplanin, rifampicin, doxycycline, quinupristin/dalfopristin, cefoxitin, trimethoprim/sulfamethoxazole, chloramphenicol, linezolid and mupirocin. 2.3.2. Minimum inhibitory concentration (MIC) by Etest Isolates resistant to cefoxitin were submitted to the Etest () to determine the sensitivity to vancomycin. S. aureus ATCC 29213 was used as the quality control in each set of tests. Isolates showing inhibition zones of 30 μg cefoxitin (Oxoid, Cambridge, UK) disk, and that were positive for mecA gene by PCR, were characterized as MRSA.
ELISA formats comprising monoclonal antibodies against H. pylori proteins showed improved results compared to polyclonal approaches. The current guideline evaluates the use of the stool antigen test as equivalent to the UBT if a validated laboratory-based monoclonal antibody is used. (13) Serological Test Immune responses against H. pylori are utilized to detect infection by analyzing patients’ blood or serum for IgG and IgA antibodies. Serology is the only test which is not affected by those local changes in the stomach that could lead to a low bacterial load and to false negative results. According to guidelines proposed by the Maastricht conference, only IgG detection is considered and the favored method is ELISA.
PROCALCITONIN AS A PREDICTIVE VALUE FOR INTESTINAL ISCHEMIA AND NECROSIS IN ACUTE INTESTINAL OBSTRUCTION PATIENTS UNDERWENT URGENT OPERATION Abd-El-Aal A. Saleem1, Emad F. Kholef2 1 Department of General Surgery, Faculty of Medicine, Aswan University, Aswan, Egypt. 2 Department of clinical pathology, Faculty of Medicine, Aswan University, Aswan, Egypt. Correspondence to Abd-El-Aal A. Saleem, MD, Department of General Surgery, Faculty of Medicine, Aswan University, Aswan, Egypt. Tel. : 0020 93 460 8283 – 0020 100 120 3179 e-mail:email@example.com ABSTRACT OBJECTIVE To assess the value of procalcitonin for early detection of intestinal ischemia
Pharmacokinetics and pharmacodynamics of (S)-ketoprofen co-administered with caffeine: a preclinical study in arthritic rats Abstract: The purpose of the present study was to determineing if whether caffeine modifies the pharmacokinetics and pharmacodynamics of (S)-ketoprofen following oral administration in a gout-type pain model. 3.2 mg/kg of (S)-ketoprofen alone and combined with 17.8 mg/kg of caffeine were administered to Wistar rats and plasma levels were determined between 0.5-24.0 h. Additionally, antinociception was evaluated based on the protocol of the PIFIR model before blood sampling between 0.5-4.0 h. Significant differences in Cmax, AUC0-24 and AUC0-∞ values were observed with caffeine administration (p < 0.05). Also, Ssignificant differences in Emax, Tmax and AUC0-4 values were determined when comparing the treatments with and without caffeine (p < 0.05). By relating the pharmacokinetics and pharmacodynamics data, a counter-clockwise hysteresis loop was observed regardless of the administration of caffeine. When the relationship between the
ABSTRACT The objective of this long term study was to evaluate anti- diabetic activity of Artemisia absinthium( methanolic leaf extract of Artemisia absinthium - MLEAA) in Streptozotocin induced experimental diabetes mellitus in normal adult male Wistar rats via comparison of changes in body weight , levels of plasma glucose and insulin , among the empirical groups. About 32 experimental rats male were divided into four groups, eight in each group; Normal (N), Normal treated (NT) with MLEAA, Diabetic (D) and Diabetic treated (DT) with MLEAA. Experimental diabetes mellitus was induced by a single dose intraperitoneal injection of Streptozotocin (55 mg/kg body weight) in respective groups meant for Diabetic (D) and Diabetic Treated (DT).
To measure the impact of the 2 randomized interventions (WASH and IYCF) on incidence, prevalence, and severity of diarrheal disease in infants, stratified by maternal/infant HIV status. To model the relative contributions of diarrheal disease and EED in mediating the effects of improved WASH on child length and hemoglobin concentrations, stratified by maternal/infant HIV status. To measure the strength of association between severity of maternal EED and systemic inflammation during pregnancy with the risk of 6 adverse birth outcomes (miscarriage, stillbirth, premature delivery, fetal stunting, low birth weight and neonatal death), stratified by maternal HIV