Importance Of Agglutination

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ABSTRACT
This paper scrutinises on the importance of agglutination reactions in clinical testing and diagnosis of various diseases. The ability of various antigens and antibodies to agglutinate when mixed in desired environment has been used as the basis to detect the presence of respective antigens in body. It focuses on importance of this method as it gives the results faster than various other methods and provides visible results. Diagnosis of various diseases can be done by this method provided the antibodies are present in blood, urine, plasma or fluid of bone marrow. The following paper discusses the clinical application of agglutination reaction in testing the ABO, Rh blood grouping, test for typhoid
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The reactions involving such kind of antigen and antibody interaction are known as agglutination reactions. This type of reaction occurs at the surface of erythrocytes, bacterial cells or animal cells at which the antigens are present [1].The results of these reactions are clearly observable since they form large sedimented particles in form of visible clumps. Formation of clumps is due to antigen and antibody complex formation. The ease of its performance and identifiable results make it viable for large clinical importance. Its most important clinical application involves the detection of bacterial infection. This can be tested by simply mixing the serum of suspected individual which contain the antibodies with the antigens of specific bacteria the accumulation of clumps confirms the presence of particular bacterial infection.[2] This test can be performed in various ways including slide agglutination reaction, tube agglutination reaction, indirect agglutination inhibition reactions etc. Another important practical application involves blood group test of…show more content…
Rh antigen is also present on the surface of RBCs similar to A, B and O antigens. Test for Rh blood grouping can be performed easily by side agglutination test. This blood group could be the most complex one of all blood type systems since it involves 45 different antigens on the surface of red cells that are controlled by 2 closely linked genes on chromosome 1.[5] The inheritance of this trait can easily be predicted by knowing the simple genetic concept that the homozygous dominant i.e. DD and heterozygous i.e. Dd are Rh +ve and homozygous recessive i.e. are Rh

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