Salbutamol Sulfate Research Paper

In situ Cross-linked Matrix Tablets for Sustained Salbutamol Sulfate Release: Formulation Development by Statistical Optimization

ABSTRACT
Background: The use of natural polymers in designing of matrix tablets for sustained-release drug delivery systems has received much attention.
Objectives: The study involves the development and optimization of in situ cross-linked matrix tablets for sustained salbutamol sulfate release.
Materials and methods: In situ cross-linked matrix tablets of salbutamol sulfate were prepared by direct compression and optimized by response surface methodology based on 32 factorial design. The influence on sodium alginate and calcium carbonate amounts in salbutamol sulfate matrix tablets on the properties like drug

Response surface methodology is a widely applied approach in the development and optimization of drug delivery devices [8, 28]. The response surface methodology is applied to understand response models as fully as possible the effect of factors and their levels, over the whole of the experimental domain, and to predict the response inside the domain. Moreover, it can be used for optimizing a formula (i.e. maximizing one or more of the responses, keeping the formulation variable setting within a satisfactory range), carrying out simulations with the model equations and plotting the responses. The three-dimensional response surface graph is very useful in learning about the main and interaction effects of the independent variables (factors), whereas two-dimensional contour plot gives a visual representation of values of the response [8, 35]. The three-dimensional response surface plots (Fig. 1 and 2) and corresponding contour plots (Fig. 3 and 4) indicate the deceased values of R5h and increased values of hardness with the increment of both the independent variables (amounts of sodium alginate and calcium carbonate) investigated for the formulation optimization of salbutamol sulfate matrix