Isoxazoline Synthesis

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6.1.1:- Synthesis of Isoxazoline derivatives :- Isoxazoline are five member heterocyclic compound. isoxazole and their derivatives have received much attention because of their wide application in medicine and pesticide chemistry. Many isoxazole compound including oxacillin sulfamethoxazole have been developed as pesticides and drugs. Isoxazoline derivative synthesized by various ways [1-2].[3] reported the synthesis of isoxazolines from newly substituted chalcone by reaction with hydroxylamine hydrochloride . J.T. Desaiet al. [4] reported the ecofriendly synthesis of isoxazoline moiety containing bridge at 2 º amine and also…show more content…
[5] synthesized Mannich bases of isoxazolines derivatives by the condensation reaction of substituted acetophenone with substituted aldehydes in presence of alcoholic NaOH via chalcones intermediate. A palumbopiccionello, et. al[6] reported the synthesis of isoxazoline derivatives through Boulton –Katrizky rearrangement of 1, 2, 4, oxadiazoles. R. Bhimwal etal.[7] described the synthesis of isoxazolines via cyclisation of substituted chalcone intermediates in the presence of hydroxylamine hydrochloride and screened them for antimicrobial activity. Tejaskumar et al.[8] proposed the synthesis of isoxazolines derivatives and screened them for antimicrobial activity. Das, P. et. al [9] described the synthesis of spiro – isoxazoline and investigated the compound as anti – cancer agents. Hwang, I. T. et. al. [10] investigated the rice herbicidal activity of 5 – (2,…show more content…
For chlorination SOCl2 used. We have synthesized carboxamide derivatives using NTAA and 3-(3-benzyl-4,5-dihydroisoxazol-5-yl)pyridine and 3-benzyl-5-(3-nitrophenyl)-4,5-dihydroisoxazole by coupling reaction using dichloromethane as a solvent and the product obtained in 1.5-2 hours by stirring only. After synthesis of these carboxamide derivatives , The compounds are characterized by FTIR, 1HNMR, CMR, UV-Visible and mass spectral analysis. The analysis data is in good correlation with structure of
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