Ketorolac Tromethamine

Design and Characterization of Orodispersible Tablet of Ketorolac Tromethamine

RESULT AND DISCUSSION

Ketorolac Tromethamine is a potent NSAID agent with moderate bioavailability with highly bitter in taste. We have found that MDT technology will be better to improve bioavailability and taste masking of the selected drug. MDT tablet will releases their contents rapidly for immediate onset of action, to prevent its first pass metabolism, and to improve bioavailability. It also leads to reduction of dose and drug toxicity, which lead to improve patient compliance

The solubility of Ketorolac tromethamine was determined in different solvent systems and buffers The IR spectra of physical mixture of polymers and drug were shown in Figure 4.8.

The infrared absorption spectra of pure polymer and physical mixture of polymer and drug were run and between 4000 cm-1-500 cm-1 .

Result and Discussion 91

Ketorolac tromethamine mouth dissolving tablet Melting point-166.6 between 165 and1 70 with decomposition and contain protein binding 99.2%

For the determination of partition coefficient of human insulin, n-octanol was used as oil phase and phosphate buffer pH 7.4 was used as aqueous phase.

Phosphate buffer saline pH 7.4 and n-octanol 0.64

The absorption maxima (λmax) of ketorolac tromethamine (5 µg/ml) in this

solution was found to be 372 nm which is concordant with the Indian Pharmacopoeia

Prior to the formulation, preformulation study was carried out on drug and excipients, in the present work, formulation part divided in to four steps. In first step, preparation of preparation of dummy tablets were done by using different such as lactose monohydrate , Mannitol, microcrystalline cellulose and its combination in different ratio . The detailed composition is shown in table . The dummy tablets were also evaluated for various physical parameters such as thickness, hardness, friability, weight variations, and disintegration. The powder blends were subjected to evaluation such as angle of repose, bulk density, tapped density, % compressibility and Hausner ratio. The tablet parameters (effect of diluents on tablet) were found to be shown in table form these matrix combinations of lactose and microcrystalline cellulose were selected for further tablet