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Ketoprofen Essay

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Formulation and evaluation of niosomal drug delivery system of ketoprofen
Kaushik Kara, 1, Preethi Sudheera, 2, R. S Thakura, 3 a, 1 Department of Pharnaceutics, Krupanidhi college of Pharmacy, Bangalore-560035, India. a, 2 Department of Pharmaceutics, Associate Proff., Krupanidhi college of Pharmacy, Bangalore-560035, India. a, 3 Department of Pharmacy, Head of the department , Krupanidhi college of Pharmacy, Bangalore-560035, India.
Email ID:- kawsik.kar2010@gmail.com

Abstract
Targeted drug delivery system is used to deliver drugs in a specific area in definite concentrations. It is also called as smart drug delivery. It aims to increase the concentration of drugs in some parts of body relative to others. Ketoprofen belongs to NSAIDs which has various side effects through oral administration and it is less permeation through skin. So to increase the permeability of ketoprofen through skin, Vesicular structure called niosome have developed and this is used as drug carriers.
Niosomes is prepared by methods such as thin film hydration technique, ether injection technique. The niosomal formulations were …show more content…

Surfactant, Cholesterol was dissolved in 8ml of diethyl ether and drug was dissolved in 2ml of ethanol. The mixture was then transferred to a round bottom flask, and the solvent was evaporated under reduced pressure at a temperature 20-25ºC, using a rotary flash evaporator until the formation of a thin lipid film. The formed film was hydrated with 10 ml of Phosphate buffer saline pH 7.4. The hydration was continued for 1 h, while the flask was kept rotating at 55-65°C. The hydrated niosomes were sonicated for 20 min using a bath sonicator to obtain niosomal dispersion containing both free and entrapped drugs of varying size.

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