The optimized formulation of 0.5% Triamcinolone acetonide lecithin organogel and blank LO without drug were applied over the dialysis membrane (mol.wt.12000-14000) weighing approximately 100mg with 28ml diffusion media as 1% SLS in water. The temperature was maintained at 37±0.2 oC with magnetic stirring at 250 rpm. The samples of 1ml were withdrawn from each diffusion cells at different time intervals up to 8 hr and equal amount of diffusion media was replaced allowing to maintain sink conditions. Then samples were analysed on HPLC and dilutions were done if needed. Calculations were done and graph was plotted as Time in hr against % Cumulative drug
Abstract Liquisolid systems is an innovative technique for enhancing solubility, dissolution and bioavailability of poorly water soluble drugs. It involves changing of the drug in the liquid state into compressible and freely flowable dry powder throughout its absorption into appropriate porous carrier (e.g.microcrystalline cellulose), after that the powder coated with material has a highly adsorption capacity (known as colloidal silica). Orally disintegrating tablets represent a novel dosage form that overcomes the difficultiess of swallowing and provides a fast onset of action. Zolmitriptan is a slightly soluble drug used for treatment of acute headache of migraine; it's known to suffer from first pass effect with bioavailability of 40 %.
In the donor compartment, proliposomal formulation and control (drug suspended in sodium CMC) equivalent to 10mg of KTZ were placed separately. 30% v/v acetonitrile containing phosphate buffer saline (pH 7.4) was taken as receptor medium and kept under constant stirring upto 24 h. In order to avoid evaporation of the contents, donor compartment and sampling port are covered with aluminium foil. 500 µL of aliquots are drawn at predetermined time intervals and equal volumes have been replaced so as to maintain receptor phase volume. All the samples withdrawn were estimated for drug content using HPLC and the data was fitted into mathematical equations (zero order, first order and Higuchi models) (Szuts et al., 2010) to derive the kinetics and mechanism of drug release from proliposomal gel
During the curing, adhesive has filled all gaps. After curing, the gluing becomes leak-proof and still soft. In order to exclude the excessive epoxy adhesive, the spillway is dug. Then the most liquid adhesive flow along the spillway is excluded out of the polymer base. The spillway is important to the packaging construction to keep the reservoir from contaminating by excessive
The limit of quantification (LOQ) and limit of detection (LOD) were determined based on the slope and the standard deviation of the response using the signal-to-noise ratio (S/N) as per ICH Guidelines Q2(R1) 2005. The LODs for Lamivudine, Abacavir and Dolutegravir were found to be 0.021, 0.330 and 0.038µg/mL respectively, and the LOQs for Lamivudine, Abacavir and Dolutegravir were 0.056, 1.320 and 0.095 µg/mL respectively. (table 6 ) Robustness Robustness of the method was performed by making slight deliberate changes in the analytical methodology like flow rate and solvent ratio. It was observed that this method did not significantly affect in system suitability parameters like USP tailing factor, theoretical plates and resolution, which confirmed that the developed HPLC method is
Experiment: Density of Liquids Analysis Questions Directions: Answer in complete sentences. In your lab notebook, histogram the class data for the densities of Liquid A and Liquid B. Differentiate the boxes for each liquid with different colors or shading, and indicate this with a Key. For your horizontal axis, please use an interval width of 0.02 g/cm³ and count by odd numbers (i.e., 0.67, 0.69, 0.71, etc.). Don’t forget to give your graph a title, and label both of your axes. Once you’ve created your histogram, insert a clear photo of it in the space below.
Co., Egypt. Lipoic acid capsules (Batch No. A40158) labeled to contain 100 mg Lipoic acid per capsule were purchased from the Canadian market (WN Pharmaceuticals®.Ltd, B.C., Canada V3k 7B5.) Instrument Fluorescence spectra and measurements were carried out on a Perkin-Elmer LS 45 luminescence spectrometer, equipped with a 1-cm quartz cell. The instrument is interfaced to a computer loaded with FL
The graphite rod was inserted as anode into the ionic liquid (IL)/water solution, placed parallel to the Pt wire as counter-electrode with a separation of 1 cm and the ionic liquid urea choline chloride was mixed with water at 1:1 ratio. Using a DC power supply the potentials of 5 V were applied to the two electrodes. The exfoliation products were washed with water and surfactant until the pH became neutral and the products were separated by ﬁlter and ultra-centrifugation at 10,000 rmp at 25 ºC2. 2.2 Preparation of SRGO Synthesis of SRGO was carried out using the method described by He et al.24 and the process of SRGO production is shown in Fig. 1.
Low- VOC assembly: Materials installed with minimum VOC producing compounds, or no VOC mechanical attachment methods and minimum hazards. Moisture resistant: Products and systems that resist moisture or inhibit the growth of biological contaminants in the buildings. Healthfully maintained: Materials, components, and the systems that simply require only, non-toxic, or method cleaning of the low VOC. Systems or equipment: By identifying indoor air pollutants or improve air quality, these products are to promote healthy indoor air
Highly viscous fluid is thicker due to higher concentration gradient and molecules move more slowly around each other. This leads to reduce of diffusion rate . Gathering the viscosity data on a material gives manufactures the ability to predict how material will behave. It also helps in how the transportation processes are designed . The printing ink industry is one of the best examples to illustrate the need for viscosity measurement.