ipl-logo

Zolmitriptan Case Study

887 Words4 Pages

According to the information shown in Figure (6), liquisolid compacts technology with the assistance of non-volatile solvent was used for the preparation of liquisolid formulation of fast release tablets of Zolmitriptan. Zolmitriptan tablets are available in the market at doses of 2.5 mg and 5 mg . Dose of 2.5 mg was selected for the present study. Figure (6): Graphic representation of the preparation of liquisolid systems The preparation of the liquisolid systems involve the following steps: Firstly, the calculated quantities of Zolmitriptan and PG were precisely weighed and mixed together in 20 ml glass beaker, heated to 80 0 C in water bath sonicater for 15 minutes until homogenous drug solution of the liquid medication was obtained. After that, the resulting liquid solution (Zolmitriptan and PG ) was …show more content…

 Secondly, the obtained blend was uniformly spread as a homogeneous layer on the surface of the mortar and left standing for five minutes to allow the liquid medication to be absorbed inside powder particles.  Thirdly, the powder was scraped from mortar surface by means of a spatula and blended with a calculated quantity of superdisintegrant 5% (w/w) for 10 minutes. Sodium starch glycolate (SSG) was used in the all liquisolid formulations, then the final mixture was lubricated with 1% magnesium stearate for two minutes. Lastly, the prepared formulations were compressed manually into cylindrical tablets by using a single punch tablet press machine of die sizes measuring 6 and 8 mm. The optimized formulation with optimal R value, drug concentration and loading factor was determined according to the flow properties and in-vitro dissolution studies. 2.3.4.1 Flow Properties of the Prepared Liquisolid Powder

Show More
Related

  • Procion Red Dye Lab Report

    1454 Words  | 6 Pages

    While the solution dissolved, 50 mL of distilled water was added to a 150 mL beaker and heated on the hot plate. When the solution started to boil 2.65 grams of Na2SiO3*5H2O was added to the beaker with a stir bar and heated to a gentle boil. When both solutions began to boil, the sodium silicate solution was slowly added to the sodium aluminate. The solution was kept at 900C for 60 minutes and stirred with stir bar. After 60 minutes, the zeolite solution was cooled for 5 minutes and for the magnetized zeolite , 0.78 grams of FeCl3 and 0.39 grams of FeSO4*7H2O was added to the flask and stirred until the iron parts dissolved.

    Read More

  • Nt1310 Unit 4 Coursework

    1433 Words  | 6 Pages

    Coursework Equipment List • Boiling tubes (8) I will use these because this is where I will mix both the sodium carbonate and the strontium nitrate in order to form the precipitate. I need 8 because I am going to add 8 different amounts of strontium nitrate (1-8cm³) to the 8cm³of sodium carbonate. • Measuring cylinder (1) I will use this to measure the 8cm³ of sodium carbonate and the varying amounts of strontium nitrate to put into the test tubes. • Sodium Carbonate (enough to fill 8 boiling tubes with 8cm³/64cm³)

    Read More

  • 6.03 Calorimetry Lab

    775 Words  | 4 Pages

    Next, about 10 mL of both solutions, Red 40 and Blue 1, were added to a small beaker. The concentration of the stock solution were recorded, 52.1 ppm for Red 40 and 16.6 ppm for Blue 1. Then, using the volumetric pipette, 5 mL of each solution was transferred into a 10 mL volumetric flask, labelled either R1 or B1. Deionized water was added into the flask using a pipette until the solution level reached a line which indicated 10 mL. A cap for the flask was inserted and the flask was invented a few times to completely mix the solution. Then, the volumetric pipette was rinsed with fresh deionized water and

    Read More

  • Copper Transformation Lab Report

    1931 Words  | 8 Pages

    After I obtained this and measured the mass to make sure I had the right amount, I then added it to my blue solution from the last step of the lab. I placed a watch glass on the beaker and continued to watch the chemical reaction take place and recorded what happened. There was lots of bubbling and come condensate that formed on the watch glass. The Zn began to transform into copper and started floating on top of the liquid after the blue color quality was changed into clear. I stirred periodically to make sure all the bubbling was finished.

    Read More

  • Quetiapine Fumarate Case Study

    3223 Words  | 13 Pages

    Introduction: Quetiapine Fumarate (QF) is a psychotropic agent indicated for the treatment of schizophrenia and manic episodes associated with bipolar disorder. QF possesses good solubility in aqueous fluids (1) and ethanol. Quetiapine is available in the market with the brand name of Seroquel XL (2). Inadvertent, rapid drug release in a small period of time of the entire amount or a significant fraction of the drug contained in a prolonged release dosage form is often referred to as “dose dumping”. Jhonson F. et al.

    Read More

  • Rf Value Lab Report

    391 Words  | 2 Pages

    After finding the Rf values of the four known compounds, solvent 1 (99.5% ethyl acetate/0.5% acetic acid) was chosen, due to the wide range of results, for the remaining experiments. Ibuprofen, our known tablet, gave a similar Rf value to our previous results for Ibuprofen. For Anadin extra, there were three compounds identified as Caffeine, Paracetamol and Aspirin as the Rf values of the drug were close to the values of these three compounds in the first part of the practical. For both of these known drugs, the Rf values acquired were close to my predictions before the experiment. For the unknown powder, we obtained Rf values of 0.52 and 0.76 so we believe that the unknown powder contains Aspirin and Ibuprofen.

    Read More

  • Tetraphenylnaphthalene Lab Report

    779 Words  | 4 Pages

    The solution continued to boil for 25 more minutes until a

    Read More

  • O-Vanillin Lab Report

    840 Words  | 4 Pages

    However, after refluxing for a while, yellow precipitates begin to form near the top of the flask. It was assumed that the remaining starting material was concentrated from a decrease volume to reappeared in solution. Nevertheless, this may have been a sign of contamination that will negatively affect the entire reaction. This observation later resulted in a yellowish

    Read More

  • Hydrated Copper Sulfate Lab Report

    1366 Words  | 6 Pages

    With the two reactants being aqueous solutions, there is a possibility it the reaction could form a precipitate as one of

    Read More

  • Diels Alder Reaction

    400 Words  | 2 Pages

    =O groups present in the final product. This showed that my final product was not very pure and that there was a lot of contamination in the second part of the

    Read More

  • Binary Liquid Vapour Phase Diagration Lab Report

    1855 Words  | 8 Pages

    The mixture was then distilled. When the temperature was reached to about 59℃, half vial of distillate (1V) and 1 mL of the liquid residue (1L) were collected. For 61.0℃, the distillation was then continued. Samples (2V, 2L) were taken at about 61.0℃.

    Read More

  • Limiting Reagent Lab Report

    519 Words  | 3 Pages

    Introduction: The objective of the experiment is to determine the limiting reagent in a chemical reaction. The principles of stoichiometry and limiting reagents will be used to predict the amount of product formed. The amount of product formed and the change in the color of the solution upon mixing of two reactants are being used to predict the limiting reagent and calculate the theoretical yield in grams. My hypothesis was that with the reaction of the zinc with the copper sulfate solution that it would dissolve the zinc to determine the limiting reagent.

    Read More

  • 6.03 Chemistry Lab

    289 Words  | 2 Pages

    5. 150 ml of the solution in beaker A was added to the separating funnel with 10ml of chloroform. The funnel was gently shaken and vented to release the pressure. This was done five times. 6.

    Read More

  • Bromination Lab Report

    785 Words  | 4 Pages

    This verified the formation of the major products. Overall, one can say that the experiment was

    Read More

  • Buffer Lab Report

    1344 Words  | 6 Pages

    Introduction Buffer is a solution that resists a change in pH when bases or acid are added. Solutions that are acidic contain high concentrations of hydrogen ions (H+) and have pH values less than seven. Buffer usually consist of a weak acid, and its conjugate base or a weak base and its conjugate acid. The function of buffer is to resist the changes in hydrogen ion concentration as a result of internal and environmental factor. This buffer experiment is important so that we relies the important of buffer in our life.

    Read More

More about Zolmitriptan Case Study

Open Document