2.5 LIQUISOLID TECHNIQUE
2.5.1 Introduction [14]
With the liquisolid technology, a liquid may be transformed into a free flowing, readily compressible and apparently dry powder by simple physical blending with selected excipients named the carrier and coating material. The liquid portion, which can be a liquid drug, a drug suspension or a drug solution in suitable non-volatile liquid vehicle, is incorporated into the porous carrier material. Fig. 2.7 Liquisolid System Representation
The liquisolid compacts are acceptably flowing and compressible powdered forms of liquid medications. The term liquid medication refers to liquid lipophilic drugs or water-insoluble solid drugs dissolved in suitable water-miscible non-volatile solvent systems
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To calculate the required amounts of powder excipients (carrier and coating materials) a mathematical approach for the formulation of liquisolid systems has been developed by Spireas. This approach is based on the flowable (Ф-value) liquid retention potential introducing constants for each powder/liquid combination. The Ф-value of a powder represents the maximum amount of a given non-volatile liquid that can be retained inside its bulk [w/w] while maintaining an acceptable flowability. The flowability may be determined from the powder flow or by measurement of the angle of repose. The terms “acceptable flow and compression properties” imply the desired and thus preselected flow and compaction properties which must be met by the final liquisolid formulation. Depending on the excipient ratio (R) of the powder substrate an acceptable flowing and compressible liquisolid system can be obtained only if a maximum liquid load on the carrier material is not exceeded. This liquid/carrier ratio is termed liquid load factor Lf [w/w] and is defined as the weight ratio of the liquid formulation (W) and the carrier material (Q) in the …show more content…
• Omit the process approaches like nanonisation, micronization techniques.
2.5.4 Disadvantages [16]
• Formulation of high dose lipophilic drugs the liquisolid tablet is one of the limitations of this technique.
• In order to achieve acceptable flowability and compactability for liquisolid powder formulation, high levels of carrier material and coating materials should be added. This will increase the weight of tablets to above one gram which makes them difficult to swallow. Consequently, it is impossible with conventional tablet methods to convert high dose to liquisolid tablets with a tablet weight of less than 50mg. Dissolution profile enhancement occurs in the presence of low levels of hydrophilic carrier, where coating material is not significant.
• High levels of carrier and coating materials are required to maintain acceptable flowability and compatibility for liquisolid powder formulation and that in turn will increases the weight of each tablet above 1 gm which is very difficult to swallow.
2.5.5 Mechanisms of Enhanced Drug Release from Liquisolid Systems [15]
• Increased Aqueous Solubility
• Increased Drug Surface
In this lab we were trying to figure out if Salt Creek and Barker Lake had the correct chemical balances to sustain catfish for the years coming. In order to find this out, we tested the water using a Hach Water Testing Kit. Inside were dissolved oxygen reagent powder pillows 1, 2 and 3 which we added and mixed into our sample water to prepare it for testing. Then we added droplets of Sodium Thiosulphate Solution into the prepared water too see how much dissolved oxygen parts per million were in the water. Our independent variable in this experiment was the 5 different testing sites that we went to for water samples.
K.D.A. Saboia et al. , (2007) have been prepared the Bi4Ti3O12–CaCu3Ti4O12 {[BIT(X)–CCTO(100-X)]} composite powders through solid state reaction method and calcined in the range of 900 to 1020 ºC for 12 h. The as-prepared powders have modified in the form of thick film onto alumina ceramic substrate by utilizing screen printing. At 100 Hz, the value of dielectric constant (κ) of CCTO100 and BIT100 is 316.61 and 53.64 respectively. Conversely, the composite with X=20 % shows an unexpected dielectric constant of 409.71, which is around 20% higher in comparison with the CCTO.
The purpose of this report is determine if sodium chloride is a viable option as a deicer on winter roads. To determine this, one must compare a multitude of factors. In this lab, the freezing point depression of water, enthalpy of dissolution, cost, and environmental impact will be discussed. A large factor in how effective a substance is as a deicer is it’s ability to decrease the freezing point of water. If the freezing point of water can be lowered, the outside temperature must be much colder to reach this new freezing point, resulting in less ice on the roads.
First of all, an alka-seltzer is an a little tablet that helps with multiple pain. For example, alka-seltzer helps with migraines, headaches, sinus headaches, muscle pain, and symptoms of pain. Alka-seltzer contains aspirin, sodium, hydrogen carbonate, citric acid, natural flavors, and artificial flavors. These are just some of the ingredients. When an alka-seltzer dissolves it releases all of the medicine.
The lab started off by measuring critical materials for the lab: the mass of an an empty 100 mL beaker, mass of beaker and copper chloride together(52.30 g), and the mass of three iron nails(2.73 g). The goal of this experiment is to determine the number of moles of copper and iron that would be produced in the reaction of iron and copper(II) chloride, the ratio of moles of iron to moles of copper, and the percent yield of copper produced. 2.00 grams of copper(II) chloride was added in the beaker to mix with 15 mL of distilled water. Then, three dry nails are placed in the copper(II) chloride solution for approximately 25 minutes. The three nails have to be scraped clean by sandpaper to make the surface of the nail shiny; if the nails are not clean, then some unknown substances might accidentally mix into the reaction and cause variations of the result.
Genetic engineering is changing the DNA code to express different traits. A plasmid is a circular piece of DNA that contains important genetic information. Recombinant DNA is the product after inserting your desired genes. The genes we hoped to insert in the pGLO lab were the GFP gene and the ampicillin resistance gene. GFP was needed so that we would tell if the ampicillin resistance gene had been properly placed when the bacteria glowed under a UV light.
Introduction: Quetiapine Fumarate (QF) is a psychotropic agent indicated for the treatment of schizophrenia and manic episodes associated with bipolar disorder. QF possesses good solubility in aqueous fluids (1) and ethanol. Quetiapine is available in the market with the brand name of Seroquel XL (2). Inadvertent, rapid drug release in a small period of time of the entire amount or a significant fraction of the drug contained in a prolonged release dosage form is often referred to as “dose dumping”. Jhonson F. et al.
Introduction: In this assignment, I will be doing two experimentations on examining the impact of temperature on the Alka-Seltzer’s response time. The first experimentation that I will be doing involves some water that is room temperature. The second experimentation that I will be doing involves some water that is very hot. If I want to be able to figure out the impact of the temperature on water, I will have to document the time it will take for the Alka-Seltzer to go into solution.
Finding the empirical formula for hydrated copper sulfate using calculations to find the amount of each element present in the copper ion, sulfate ion, and water while also comparing the empirical formula to a literature value. Christian Cooper Alexis Powers CHM1210-18M/Gregory Bowers 11-5-15 Purpose: To begin, there are several different goals, techniques, and claims to note in the experiment involving hydrated copper sulfate. The overall goal of this experiment is to find the empirical formula and compare it with a literature value. Yet, in finding the empirical formula of hydrated copper sulfate, there are several process for it to get through, like finding the percentages of copper, water, and finally sulfate.
In acidic aqueous solution, a buffer is formed by the dissociation of the acid: HA ⇄ H+ + A- Hence, when acid is added, the excess H+ reacts with the A- to form more HA, lowering the pH and minimising the effect of the addition of acid. When alkali is added, the OH- reacts with the dissociated H+ to form water, which reduces the effect of the alkali by restoring the pH to normal levels. Alka Seltzer acts as a buffer because the citrate ions in solution (C6H5O73-) are able to react with H+ when acid is added, to form citric acid, C6H8O7. This neutralises the acid, increasing the pH. The excess HCO3- ions also react with H+ to form CO2 and water, hence lowering the pH and reducing the acidity of the solution. The HCO3- ions also act as a buffer when alkali is added, because they react with OH- to create water and CO32- ions, increasing the pH and reducing the effect of the addiction of alkali.
Problem: How does the temperature of water used to dissolve an Alka-Seltzer tablet affect the amount of time it would take for the tablet to completely dissolve? An Alka-Seltzer tablet is a medicine tablet made with baking soda used as a pain reliever for “headaches, body aches, pain, heartburn, acid indigestion, and sour stomach” (Alka-Seltzer Tablets). It is put into water, left to dissolve and then consumed. When an Alka-Seltzer tablet is dropped into h20, a chemical reaction immediately takes place and produces bubbles made out of carbon dioxide as a product of the collision (Olson 2). When in its original powder (dry) form, the Alka-Seltzer’s two main ingredients: citric acid and sodium bicarbonate are just there and not reacting to each
CLAIRE MUNTING 29/01/2018 Criterion C EFFECTS OF SURFACE AREA OF CALCIUM CARBONATE UPON RATE OF REACTION Calcium Carbonate Chips 1 Introduction: Within the current investigation, the effects of the surface area of Calcium Carbonate (CaCO3) in combination with Hydrochloric acid (HCl) upon its rate of reaction. CaCO3, commonly referred to as limestone, is an organic substance and is, in a sense, the crystallised “carbonic salt” of the element, calcium2. In addition to being a salt, the pH level of Calcium Carbonate is 9.91, and it is therefore, a basic substance, due to the fact that it is comprised of a pH level higher than 7, which is neutral3. HCl, however, is the bodily acid found in the stomach of human beings.
Acids are proton donors in chemical reactions which increase the number of hydrogen ions in a solution while bases are proton acceptors in reactions which reduce the number of hydrogen ions in a solution. Therefore, an acidic solution has more hydrogen ions than a basic solution; and basic solution has more hydroxide ions than an acidic solution. Acid substances taste sour. They have a pH lower than 7 and turns blue litmus paper into red. Meanwhile, bases are slippery and taste bitter.
Introduction The goal of the experiment is to examine how the rate of reaction between Hydrochloric acid and Sodium thiosulphate is affected by altering the concentrations. The concentration of Sodium thiosulfate will be altered by adding deionised water and decreasing the amount of Sodium thiosulphate. Once the Sodium thiosulphate has been tested several times. The effect of concentration on the rate of reaction can be examined in this experiment.
ABSTRACT This paper scrutinises on the importance of agglutination reactions in clinical testing and diagnosis of various diseases. The ability of various antigens and antibodies to agglutinate when mixed in desired environment has been used as the basis to detect the presence of respective antigens in body. It focuses on importance of this method as it gives the results faster than various other methods and provides visible results. Diagnosis of various diseases can be done by this method provided the antibodies are present in blood, urine, plasma or fluid of bone marrow.