Bromination is a type of electrophilic aromatic substitution reaction where one hydrogen atom of benzene or benzene derivative is replaced by bromine due to an electrophilic attack on the benzene ring. The purpose of this experiment is to undergo bromination reaction of acetanilide and aniline to form 4-bromoacetanilide and 2,4,6-tribromoaniline respectively. Since -NHCOCH3 of acetanilide and -NH2 of aniline are electron donating groups, they are ortho/para directors due to resonance stabilized structure. Even though the electron donating groups activate the benzene ring, their reactivities are different and result in the formation of different products during bromination. In acetanilide, the lone pair of the nitrogen is delocalized into the
Mol.Wt. R % yield M.P. 5a 304 H 51.08% 165-167ºC 5b 338.5 Cl 47.36% 160-162ºC 5c 318 CH3 35.9% 155-157ºC 5d 334 -OCH3 49.10% 158-160ºC 5e 347 37.70% 175ºC Step-5 Synthesis of title compounds54 (7) Equimolar amounts (0.05M) of 2-Methyl-3-[5-(4-substituted) phenyl-1,3,4-oxadiazole-2-yl]-quinazoline-4(3H)-one and the opportune benzaldehyde were reacted in glacial acetic (5.2ml) under reflux for 18 hrs. A sticky oily matter was obtained, which was then purified to remove impurities to get final product. Final compound was dried and recrystallised from hot ethanol.
The goal of this lab was to prepare methyl m-nitrobenzoate using electrophilic aromatic substitution using nitration. The reaction used methyl benzoate with the acid catalyst as sulfuric acid. The mechanism for the nitration using methyl benzoate is presented in Figure 1. Figure 1: Benzene can only undergo substitution reactions that are called electrophilic aromatic substitution reactions. Given that benzene rings are used commonly in the production of many organic compounds, the capability to make substitutions to benzene is critical.
Kolbe-Schmitt Reaction Kira Wall (CHE433) 12-3-14 The Kolbe-Schmitt reaction is named after Hermann Kolbe and Rudolf Schmitt. Schmitt published his research in the Journal fur Pracktische Chemie in 1885 while Kolbe published his research in the Annalen der Chemie und Pharmacie in 1860. The reaction adds a carboxyl group onto the benzene ring of a phenol. The process uses a base carbon dioxide and acid work-up. The original reaction done by Kolbe involved the formation of sodium phenoxide through the evaporation of a molar equivalent mixture of phenol and aqueous sodium hydroxide.
In the chemical reaction below, determine the reducing agent. Cl2(aq) + 2NaBr(aq) 2NaCl(aq) + Br2(aq) A. Cl2 B. NaCl C. Br- D. NaBr 10. An element that is oxidized is a(n) __________ agent and an element that is reduced is a(n) __________ agent. A. reducing; oxidizing B. reducing; reducing C. oxidizing; reducing D. oxidizing; oxidizing Answer Key: 1. D 2.
It is estimated that about 800,000 tonnes of sulphuric acid is produce to meet the market’s demand. This chemical is widely used in the latex industry to coagulate rubber, electronic industry as an etching agent, the palm oil industry as a neutralizing agent, and as a base chemical for many chemical industries. Sulphuric acid is also heavily in used for the manufacturing of fertilizers and in the automotive industry. Blooming agriculture industry in the country and the increasing production of automotive has contributed huge needs for sulphuric acid. The worldwide production of the sulphuric acid stands around 200 million tonnes per annum.
Byproduct produces from this reaction by weight percentage (% wt) base on acrylonitrile are acetonitrile 2-4 % and hydrogen cyanide 14 to 18 %. This byproduct can be market for any other purposed and there are still demands in the chemical industry. The reaction product will be absorb in vapor phase and turn in aqueous phase before being transfer to the distillation column. Most of the acrylonitrile and hydrogen cyanide will be distilled from acetonitrile and water in the first stage of distillation process. While hydrogen cyanide will be remove in the next phase of distillation.
One purpose of a Wittig reaction is the formation of alkenes from aldehydes or ketones employing a carbo-phosphorous ylide, which is stabilized vie resonance to allow for the carbon bonded to phosphorus to be deprotonate from by a base (Ketcha, 142). The resonating ylide will react with the electrophilic carbonyl carbon of its aromatic aldehyde to produce a betaine intermediate, or a crystalized 4