1.6.2. Instant release Dissolution rate of the drugs commonly selects its rate and amount of bioavailability. Due to the improved solubility and wet capability of the drugs concluded the development of inclusion complexes, Hydrophilic cyclodextrins aids in cumulative the oral bioavailability of steroids, non- steroidal anti- inflammatory drugs, antiepileptic, anti -diabetics, vasodilators. 1.6.3. Sustained release Alkylated and acylated products of Cyclodextrins which are hydrophobic in nature are used as gentle release movers for water soluble drugs.
Solubility: It is insoluble in propylene glycol, water and glycerin; soluble in methyl aetate, chloroform, and tetrahydrofuran, in mixtures of hydrocarbons (HC) with ethanol. Functional Category: Flavouring agent, tablet binder and filler, coating agent and viscocsity increasing agent. Applications in Pharmaceutical Formulation or Technology: Ethyl cellulose (EC) is widely used in topical as well as oral formulations. It is coated mainly to mask the unpleasant taste and to increase the stability of the formulations, and granules to inhibit the oxidation. Ethyl Cellulose of high grades are used mainly in
Background: Adjuncts to local anaesthetics for brachial plexus block may enhance the quality and duration of analgesia. Midazolam, a water-soluble benzodiazepine, is known to produce antinociception and enhance the effect of local anaesthetics when given epidurally or intrathecally. Aim: Study was to assess the effect of Midazolam added to brachial plexus block by supraclavicular approach. Materials and Methods: A prospective, randomized, single blinded study was conducted on 100 ASA Grade I or II adult patients undergoing upper limb surgeries under supraclavicular brachial plexus block. Patients were randomly divided into two groups.
It was then collected on Hirsh funnel by filtration. Melting point determination was performed to test for the purity of the drug (tablet). Hypothesis It was hypothesized that crude paracetamol melts at 165.1℃ while pure paracetamol melts at 170.5℃. Background information Paracetamol is a commonly used medicine. It is known as a mild
FORMULATION OF ENTERIC COATED TABLETS OF PANTOPRAZOLE SODIUM Formulation design: Pantoprazole enteric coated tablets were prepared using different polymers like HPMC 5cps (sub coat) AQOAT, CAP and KOLLICOAT MAE 30DP. Different formulations of pantoprazole sodium enteric coated tablets were prepared using the polymers in different ratios keeping core tablet (C3) constant. They are assigned with formulation codes. GENERAL FORMULATION A formula is set using following ingredients: Coating polymer - HPMC 5cps, CAP, AQOAT, KOLLICOAT MAE30DP Solvent - Isopropyl alcohol, Dichloromethane, Water Plasticizer - Triethyl
When intermixed with an emulsifying agent, flavouring and water, it plays the role of an abrasive, to promote oral hygiene by removing dental plague and food from teeth. Calcium carbonate (CaCO3) is a chemical compound which comprises of one calcium atom bonded to one carbon atom and three oxygen atoms. It is available in natural forms such as chalk, limestone or the shells of snails and is obtained by mining or quarrying for industrial purposes. Regardless of acid strength,it causes a reaction with acids to produce carbon dioxide. This property makes up a simple and common way to identify Calcium
Evaluation of Preformulation parameters: The Esomeprazole powders / pellets were evaluated for angle of repose, bulk density, tapped density, carr’s index and Hausner’s ratio. From the results of micrometrics studies drug shows good flow property and compressibility property. In vitro dissolution
Bioactivity guided fractionation of potent anti-acne plant extract against Propionibacterium acnes 1. Vinod Gauttam Department of Pharmacognosy, ISFcollege of Pharmacy, Moga, Punjab, India * firstname.lastname@example.org 2. Nitisha Negi Department of Pharmacognosy, ISFcollege of Pharmacy, Moga, Punjab, India * email@example.com 3. Malika Arora Department of Pharmaceutics, ISFcollege of Pharmacy, Moga, Punjab, India * firstname.lastname@example.org 4. Kavita Munjal Department of Pharmacognosy, ISFcollege of Pharmacy, Moga, Punjab, India * email@example.com ISF College of Pharmacy, Moga, Punjab, India ABSTRACT Background: Propionibacterium acnes (P. acnes) are a commensal anaerobic, Gram positive bacterium that belongs to the normal microflora.
The total phenolic and capsaicin content in red pepper extract were examineted. Anti-hyperglycemia relevant in vitro α-glucosidase inhibitory activity correlated strongly to the antioxidant activity measured by the 1, 1-diphenyl-2-picrylhydrazyl method. The high phenolic and capsaicin content-containing red pepper stalk was found to have strong α-amylase and strong α-glucosidase inhibitory effects. The pericarp and placenta had high angiotensin I-converting enzyme ( ACE) inhibitory activity and also had good α-glucosidase inhibitory profiles. Inhibition of these enzymes provides a strong biochemical basis for the management of type 2 diabetes by controlling glucose absorption and reducing associated hypertension, respectively.
ABSTRACT The purpose of this study was to investigate the efficiency of silicated chitosan in promoting tablet disintegration and drug dissolution in comparison with commonly used superdisintegrant crospovidone. Silicated chitosan was prepared by co-precipitation method and metoclopramide hydrochloride was used as a model drug for the preparation of fast dissolving tablets. Formulations containing silicated chitosan exhibited almost similar in-vitro dispersion time and in-vitro drug dissolution pattern in comparison with formulation containing crospovidone. The intimate physical association between chitosan and silica creates an insoluble, hydrophilic, highly absorbent material, consequently, resulting in superiority in water uptake, water saturation for gel formation and compatibility. IR spectroscopic studies of silicated chitosan, silica, chitosan and chitosan-silica physical mixture indicated that preparation method did not involve any chemical reaction and only physical modification occurred on chitosan particles.