Lovastatin Lab Report

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DRUG AND EXCIPIENT PROFILE DRUG NAME: LOVASTATIN (LST) PHARMACOLOGICAL CATEGORIES: Lipid Lowering Agent Anti-Neoplastic Agent HMG-CoA Reductase Inhibitors. DESCRIPTION: It was discovered by Alfred Albert and his team in 1978 at Merck. It was isolated from fungus Aspergillus terreus and is also known as Mevinolin. This was the second compound identified of this class and is two times potent than the first discovered statin Mevastatin. Lovastatin (LST) is structurally similar to hydroxyl methylglutarate (HMG), a substrate of the cholesterol biosynthesis pathway and it differs by a methyl group only at single 6th position. Lovastatin (LST) is a pro drug which is activated by hydrolysis of lactone ring. MOLECULAR WEIGHT: 404.53 MOLECULAR FORMULA:…show more content…
Solubility: Soluble in water, insoluble ether, alcohol, chloroform and soluble in mixtures of isopropyl alcohol and CH2Cl2 and their organic solvents Specific Density: 0.25- 0.70g/cm3 pH: 6.0- 8.0 Stability: Stable when stored in dry conditions and aqueous solutions are affected by micro organisms growth. Viscosity: 4000cps, HPMC K4M, HPMC E5cps Uses: It is used as a binder and as an adhesive in preparation of ointment, suspending agent, and viscosity increasing agent. 2. ETHYL CELLULOSE [68] Description: It is free flowing, white to light tan coloured powder, and tasteless. Solubility: It is insoluble in propylene glycol, water and glycerin; soluble in methyl aetate, chloroform, and tetrahydrofuran, in mixtures of hydrocarbons (HC) with ethanol. Functional Category: Flavouring agent, tablet binder and filler, coating agent and viscocsity increasing agent. Applications in Pharmaceutical Formulation or Technology: Ethyl cellulose (EC) is widely used in topical as well as oral formulations. It is coated mainly to mask the unpleasant taste and to increase the stability of the formulations, and granules to inhibit the oxidation. Ethyl Cellulose of high grades are used mainly in…show more content…
It is used as a thickening agent and it can be used to modify the drug release. It can be used even both in food products and in cosmetics. It can be controlled by diffusion from the formulation. 3. POLYMETHACRYLATES [68] Description: These are film coatings and matrix structures. They are synthetic anionic and cationic polymers of Dimethyl Amino Ethyl Methacrylates (DAEM), Methacrylic ratios. Solubility: Soluble in Methanol, in aqueous isopropyl alcohol, Ethanol, Acetone as well as in 1N Sodium Hydroxide (NaOH) and insoluble in Methylene Chloride, Petroleum ether, Ethyl acetate. Stability and Storage conditions: Stable when stored at room temperature and dispersions are stable up to 1 year after manufacturing and stored at room temperature (RT) in tight containers. Incompatibilities: Acid and/alkalies Applications: Film coating of tablets which are resistant to gastric fluids. 4. POLYVINYL ALCOHOL [68] Description: It is a synthetic polymer which is water soluble and

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