Lovastatin Research Paper

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DRUG AND EXCIPIENT PROFILE DRUG NAME: LOVASTATIN (LST) PHARMACOLOGICAL CATEGORIES: Lipid Lowering Agent Anti-Neoplastic Agent HMG-CoA Reductase Inhibitors. DESCRIPTION: It was discovered by Alfred Albert and his team in 1978 at Merck. It was isolated from fungus Aspergillus terreus and is also known as Mevinolin. This was the second compound identified of this class and is two times potent than the first discovered statin Mevastatin. Lovastatin (LST) is structurally similar to hydroxyl methylglutarate (HMG), a substrate of the cholesterol biosynthesis pathway and it differs by a methyl group only at single 6th position. Lovastatin (LST) is a pro drug which is activated by hydrolysis of lactone ring. MOLECULAR WEIGHT: 404.53 MOLECULAR FORMULA:…show more content…
Ethyl Cellulose of high grades are used mainly in micro DRUG AND EXCIPIENT PROFILE encapsulation technology. It is used as a thickening agent and it can be used to modify the drug release. It can be used even both in food products and in cosmetics. It can be controlled by diffusion from the formulation. 3. POLYMETHACRYLATES [68] Description: These are film coatings and matrix structures. They are synthetic anionic and cationic polymers of Dimethyl Amino Ethyl Methacrylates (DAEM), Methacrylic ratios. Solubility: Soluble in Methanol, in aqueous isopropyl alcohol, Ethanol, Acetone as well as in 1N Sodium Hydroxide (NaOH) and insoluble in Methylene Chloride, Petroleum ether, Ethyl acetate. Stability and Storage conditions: Stable when stored at room temperature and dispersions are stable up to 1 year after manufacturing and stored at room temperature (RT) in tight containers. Incompatibilities: Acid and/alkalies Applications: Film coating of tablets which are resistant to gastric fluids. 4. POLYVINYL ALCOHOL [68] Description: It is a synthetic polymer which is water soluble and has excellent film forming adhesive and emulsifying properties. Solubility: Soluble in water (H2O) and insoluble in organic solvents like

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