INTRODUCTION
Research Question
To what extent is genetics responsible for causing Systemic Lupus Erythematosus?
Foreword
Systemic Lupus Erythematosus is a chronic autoimmune disease wherein the immune system mistakes healthy cells as intruders and attacks them. These attacks could happen in various parts of the body. It is most commonly known as the ‘great imitator ‘as its signs and symptoms imitate that of other diseases. Lupus differs from each patient and symptoms oscillate from time to time. This makes it hard for physicians to diagnose the patient. Common symptoms include extreme fatigue, skin rashes, joint pains and sensitivity to sunlight. Organ complications are problems that lupus patients have to endure, with most experiencing problems
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The first two examples and exposure to silica dust are most usually quoted to activate and cause flares for Lupus patients, but still further research has to be made to qualify these factors. Another probable cause of the disease are hormones. Estrogen is produced by both biological sexes but it is the female population that has an abundance of it. Researchers have investigated this for years as this hormone could be the possible explanation as to why women are more susceptible to the disease compared to …show more content…
Lupus Nephritis is diagnosed to a patient in which Lupus largely affects the kidneys. This could be physically visible in the form of blood in the urine as an example, and other symptoms related to that of other kidney diseases. Lupus Nephritis has six stages: Class I – Class VI. The higher the class the more severe the implications of the disease are. Class I is the minimal mesangial lupus nephritis and for patients who are classified under this usually are in remission. The worst class, Class VI (Advanced sclerosis lupus nephritis) is embodied by a gradual progressive kidney dysfunction. This complication is the one most scientists use for research as this affects the majority of Lupus patients. Other complications could include organs such as lungs, brain, intestines, and
Family History also is positive for rheumatoid arthritis (Inflammatory changes in the joints causing pain), so we had serology (scientific study of blood or other bodily fluids) run for the erythrocyte sedimentation rate (the rate at which red blood cells settle in one hour used to detect inflammation associated with conditions such as infections, cancers, and autoimmune diseases), and looking for presence of Anti-Nuclear-Antibodies (found in patients whose immune system may be predisposed to cause inflammation against their own body
She primarily treats the geriatric population. An acute exacerbation of chronic kidney disease can also be referred to as acute on chronic kidney disease. This is typically an acute kidney injury (AKI) that occurs in a patient with normal kidney function or preexisting kidney disease. “AKI is
Systemic Lupus Erythematosus is a long term disease that causes inflammation of various tissues in the body. Symptoms associated with SLE are fever, loss of appetite, nausea, muscle aches, joint pain, fatigue, hair loss, shortness of breath, rapid or irregular heartbeat, and protein in urine, but for the most part it will depend on which part of the body is being affected. Many people with SLE have flares in which symptoms get
Lupus is the fourth leading cause in disability for women. 38% of Lupus patient has been forced to stop working due to health complications from this disease. Patients spend roughly about $6,000 in treatments alone. It is unfortunate that this disease has taken a backseat when it comes to research priorities. Hopefully as time goes by, the attention towards gaining investment will increase before more of the population has to go through this disease that makes it unbearable for an individual to live their
Lupus Erythematous Systemic Lupus Erythematous (SLE) is a chronicautoimmune disease occurring in the muscle and skeletal systems. If a person were to have Lupus Erythematous, his/her immune sys-tem would begin to attack itself, rather than outside invaders. As a result, tissues, organs, and nerves are harshly affected. According to the Lupus Foundation of America (2017), SLE affects more than 1.5 million Americans, mainly ranging from ages 15-44, but most commonly in young African-American women. Cause The cause of Systemic Lupus Erythematous is unknown, however there are several fac-tors that may have an effect on the symptoms and disease.
Dermatomyositis is an uncommon inflammatory muscular disease, which involves the degeneration of collagen, discoloration and swelling of the skin and underlying muscle. Dermatomyositis is known by it’s distinctive skin rash and muscle weakness. Dermatomyositis affects children and adults, but it usually affects children between the ages of five and fifteen, and it occurs in adults in their late forties through sixties. Dermatomyositis is also more commonly found in females than males.
Discovered in 1989, Cystic Fibrosis is the most common, fatal genetic disease in the United States. Statistics show that 30,000 people in the US have been named with this disease. (Genome) Cystic Fibrosis is a disease caused when the CFTR (Cystic Fibrosis Transmembrane Regulator) is defective and the cells do not release the right amount of chloride. This causes for the body to produce thick, sticky mucus that clogs up the lungs, leads to infection, blocks the pancreas, which stops the digestive enzymes from reaching the intestine. Symptoms require; salty tasting skin, wheezing, shortness of breath, persistent coughing, poor growth or weight gain, frequent/bulky stool, and male infertility.
“I’m sorry Mrs. Bainrich, but Marcus has Goodpasture syndrome, an INCURABLE autoimmune kidney disease in which antibodies attack the basement membrane in the lungs and kidneys, leading to bleeding from the lungs and kidney failure. The antiglomerular basement membrane (GBM) antibodies primarily attack the kidneys and lungs, although, generalized symptoms like malaise, weight loss, fatigue, fever, and chills are also common, as are joint aches and pains…. “INCURABLE, INCURABLE, INCURABLE”; the word echoed over and over again in his mother’s ears as she threw herself to the ground in agony. Knowing that she wouldn’t be able to see her son graduate, go to prom, or even get married weakened her both physically and emotionally. The doctors gave her a sedative to calm her down,
When people with Celiac eat gluten, their immune system damages the villi
The skin is affected because lupus can cause rashes and lesions on the skin. This is also why the sun can make lupus worse. Many people with lupus also experience muscle pain which affects the musculoskeletal system. This can cause weakness and loss of strength for the patient. Lupus affects the nervous system through neurological dysfunction.
aegan Hope 02/10/2018 PHIL-2306-I02 Dr. Griffin Nelson Organ Donation and Relativism Five years ago, Selena Gomez was diagnosed with lupus. “According to the Mayo Clinic, lupus is a chronic inflammatory disease that occurs when your body’s immune system attacks your own tissues and organs” (abc news). Gomez was told by doctors she had lupus nephritis and that she would be needing a kidney transplant. Luckily her friend, the star of ‘Secret Life of the American Teenager”, Francia Raisa, donated a kidney to her. “Not everyone is lucky enough to have a donor.”
Because it has so many different symptoms, it is extremely difficult for doctors to recognize. When a patient first gets a tick bite, they usually contract a bull’s eye rash which “starts as a small red spot that expands over a period of days or weeks, forming a circular, triangular, or oval-shaped rash” (“Lyme Disease Overview”). However, this rash, scientifically called erythema migrans, only appears in seventy to eighty percent of Lyme disease victims, making the disease even harder to diagnose. Early symptoms of Lyme disease include flu-like symptoms such as fevers and chills, joint pain, and muscle aches. After a couple months, victims of Lyme disease may develop many symptoms such as facial paralysis, poor memory, weak limbs, heart problems, and swollen joints.
Lupus is also a disease of flares, the symptoms worsen and you feel ill, and remissions (the symptoms improve and you feel better). (Wallace) Common symptoms of Lupus includes feeling very tired and having joint pain or swelling (arthritis), a fever, and skin rashes. The rash often happens after you have been in the sun. People with Lupus may suffer from mouth sores and hair loss.
On behalf of all of us at UCSF, I would like to thank you for choosing us to be your healthcare provider. Our mission in the Division of Rheumatology is to help patients manage rheumatic and autoimmune diseases, while advancing novel research and training the next generation of rheumatologists. Beyond caring for patients in our clinics, UCSF researchers work to understand the underlying mechanisms that cause rheumatic diseases. In addition, our faculty works side by side with trainees, providing guidance and mentorship to ensure that future generations receive the same high-quality care. It is because of this unique combination of research and training that the rheumatology program at UCSF is one of the top in the nation, according to the
A person does inherit a tendency to develop the disease. It may appear when the body goes through hormonal and physical changes or after dealing with highly stressful situations (MHA,