B Cell Lymphoma Research Paper
CHAPTER 1: INTRODUCTION
1.1 Research Background
Diffuse Large B- Cell Lymphoma (DLBCL) has affected so many people all over the world including Malaysia with more than 3000 cases of lymphoma occur annually and almost 90% of the cases are Non- Hodgkin Lymphoma (Chye, Rampal, & Yahaya, 2008). The diagnosis and treatment strategies for this lymphoma are complicated since it is further divided into several subtypes which complicate the prognosis. In addition, DLBCL requires attention in term of its management that includes choice of treatment and the economic capacity of patients. Combination of Rituximab with Cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy regimen is the best medication used to cure DLBCL (Gan et
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B-cell lymphoma occurs when there is transformation of normal B cells during different stages of differentiation. It also could occurs due to transformation from less aggressive lymphoma like follicular lymphoma. Diffuse Large B- cell Lymphoma contributes to major cases of Non- Hodgkin Lymphoma (NHL) and it is aggressive in term of its behavior, which cover for almost 40% of all NHL cases (Gan et al., 2014). DLBCL is the common lymphoid malignancy that affect the development of B-cells. The disorder resulted in the uncontrollable division of aggressive, large mature B-cells which could be dangerous (Fadhilah, 2009). The immature B-cells keeps dividing and could fill the spaces in healthy tissues and well as other …show more content…
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