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Mammalian Timeless

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DNA replication is a fundamental aspect of life & is essential for preservation of genome integrity. Environmental factors or drugs can cause DNA damage or lesions that lead to arrest of DNA replication forks. Replication fork arrests are among the most serious threats to the genomic integrity because they might collapse, break & are thought to be cause of many mutations & chromosomal aberrations (1-2). Eukaryotic cells are equipped with a complex repertoire of responses to DNA damage including several pathways of DNA repair & cell cycle checkpoints (3-5). In humans, defects in this checkpoint can cause genetic instability, which in turn leads to a variety of genetic disorders & cancer (6).
Mammalian Timeless (TIM) is a multifunctional protein

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