Recurrent Medulloblastoma, brainstem compression and occurrence of refractory essential hypertension: a case report ABSTRACT Brainstem compression1-5 leading to systemic hypertension has been reported in case reports and series. This is a case report of a 4 year old male child previously operated for medulloblastoma. He was readmitted with tumour recurrence with leptomeningeal spread involving the brainstem leading to severe refractory hypertension with raised intracranial pressure and finally succumbing to it. A tentative conclusion can be made regarding occurrence of hypertension and fatality in recurrent medulloblastoma. INTRODUCTION Medulloblastoma arise from embryonic medullobastic cells located in the anterior and posterior medullary …show more content…
The patient had been previously operated 3 months back for sub-occipital craniotomy with a right sided ventriculoperitoneal (VP) shunt prior to the definitive surgery. Tumour marker studies showed a high level of MIB1 (an antibody against a protein called Ki-67, expressed in proliferating cells) of 35%. Examination revealed the patient was febrile but conscious and oriented with normal movements of all 4 limbs but a positive kerning’s sign. The hematological investigations showed leucocytosis (count of 15,700) and cerebrospinal fluid examination was consistent with the picture of bacterial meningitis. Intravenous antibiotics vancomycin and meropenem were started after verifying renal status. The shunt was initially exteriorized followed by removal under anesthesia. When the patient became afebrile a left sided medium pressure VP shunt was inserted. In the postoperative period in the neurointensive care unit (NICU) the patient became drowsy and had to be intubated and put on mechanical ventilator support. During the NICU stay the patient had multiple episodes of generalized tonic clonic seizures for which clobazam and levetiracetam were administered. An elective tracheostomy was done in view of persistent low GCS and poor respiratory effort. The patient subsequently developed high blood pressure …show more content…
The first series to appear was from Janetta and Gendell9 in which they found out those patients who had vascular compression of the medulla between 9th and 10th cranial nerve and the inferior olive had essential hypertension. There are studies to voice the fact that medullary compression leads to hypertension regardless of laterality of pressure10. Also corollary evidence exists in form of reports of resolution of hypertension after decompression of the posterior fossa, as in craniovertebral junction anomaly type-1 where the pressure was exerted at the junction by the herniated cerebellar tonsils11. One of the possible areas of stimulation intraoperatively producing systemic hypertension rise is the rostral ventrolateral medulla (RVLM). Similarly levy and colleagues reported a series of 12 patients who underwent microvascular decompression of the left RVLM for severe medically refractory hypertension as a primary indication without underlying cranial nerve compression syndromes with good
Clinical manifestation - Cyanosis - Tachycardia - Dyspnea - Hypoxia with clubbing Management For neonates whose pulmonary blood flow depends on the patency of the ductus arteriosus, a continuous infusion of Prostaglandin E1, is started until surgical intervention can be arranged. Palliative treatment: A Bidirectional Clenn shunt can be performed at 6-9 month. Modified Fontan Procedure: systemic venous return is directed to the lungs without a ventricular pump through surgical connection between the right atrium and pulmonary
But the staff understood and Dr. Westwood got an ambulance and reached to ED. He presented with diaphoresis, motor dysfunction, paresthesia, nausea, and ascending paralysis from his leg to the upper body, arms, face and head. He became cyanotic and hyperventilating and it turned to be bradycardiac with a BP 90/50mmHg. After five hour long clinical treatment procedures were followed for tetrodotoxin poisoning, his vital signs were
Cardiac causes. 4.4. Cerebrovascular causes. 4.5. Other causes.
She then, one to two days after discharge, had another seizure-like episode. She was at Lamprey and used the wall to slowly slide to the floor. Loss of consciousness was only 30 seconds with her eyes
Other imaging test includes a positron emission tomography (PET) and an M-iodobenzylguanidine (MIBG), which detects the tiny radioactive compounds that are taken up by the tumor. If Pheochromocytoma is left untreated can cause a number of critical conditions such as a stroke, heart disease, kidney failure, and even damage the nerves of the eye. When the Pheochromocytoma is assisted with other disorders the cancerous cells brake of and spread to other parts of the body and metastasize. It will metastasize in other areas of the body but mainly directs itself to the liver, lings or the lymph system. It is a lot easier to find the tumors using images, which is why they are mostly found when the patient is getting other screenings done.
• Anesthesia injected into the spinal canal (epidural anesthesia). • Procedures to drain CSF, such as anexternal ventricular drain or lumbar drain. • Sinus or ear surgery. • Breathing oxygen forced through a mask (positive pressure ventilation). • Infections of the brain.
Cytotoxic edema is most commonly characterized by the swelling of neurons, glia and constriction of extracellular space. Cytotoxic causes of edema include: traumatic brain injury, encephalitis, meningitis, toxic ingestions and hypoxic ischemic brain injury. The final
Strategies to prevent the development of this condition emphasize the maintenance of cerebral perfusion. The patient’s blood pressure and blood gases are carefully monitored, and any abnormalities are corrected. If periventricular leukomalacia develops, treatment is directed toward the management of any subsequent complications. Caregivers are taught how to properly handle, feed, dress, and toilet their children. Physical therapy is prescribed when abnormal physical signs become apparent in order to prevent secondary deformities.
Mr. A is admitted to the critical care unit post bowel resection, splenectomy, acute respiratory distress syndrome (ARDS) and patient-ventilator dyssynchrony (PVD). He is an eighteen-year-old African American man who is placed on an IV infusion of Norcuron and Ativan. The major outcomes expected for Mr. A would be for him to be able to wean of the ventilator, be hemodynamically stable, heal adequately, tolerate his diet, have adequate bowel elimination, and be able to adjust to his life with optimal functioning. The problems that are to be manage include, being on the ventilator, being sedated, having an elevated temperature, having a low hemoglobin, post surgical bowel resection, splenectomy, hypoxia and diet intolerance.
Hispathology The pathological characteristic or features of Angiocentric Glioma are quite similar to other types of brain tumors such as astrocytomas and ependymomas. Yet, their occurrences are rare in cases and this make accurate diagnosis difficult. In general, Angiocentric Glioma is demonstrating an angiocentric pattern and it composed of diffusely infiltrating, monomorphic, bipolar spindle cells which is arranged in around blood vessels in concentric sleeves and pseudorosettes. Plus, the immunohistochemical staining result for this tumor is typically positive mostly for glial fibrillary acidic protein.
All patients were continuously monitored for non-invasive blood pressure (NIBP), heart rate (HR), oxygen saturation (SpO2), end-tidal carbon dioxide (EtCO2), electrocardiogram (ECG) and, core body temperature. Preoxygenation was provided, at least 5 minutes, with supplemental oxygen (3 L/min) administered via a face mask during the monitoring procedure. A standardized anesthetic induction and maintenance was used and all drug dosages were calculated according to ideal body weight. General anesthesia was induced intravenously with propofol (1.5–2.5 mg/kg) and fentanyl (2 µg/kg), and tracheal intubation was facilitated with rocuronium (0.8 mg/kg) in the 30° reverse Trendelenburg position. A 20- gauge catheter was placed in the radial artery for arterial blood gas samples.
Airway assessment revealed adequate mouth opening, modified Mallampati score of 2 and restricted neck extension. In operating room, under standard monitoring, patient was induced with Propofol and Fentanyl. Intubation was attempted after
In the white matter area of the medulla oblongata contains ascending and descending nerve tracks which cross the brain and spinal cord. The protrusions in the white matter forms the pyramids with corticospinal nerve connect the cerebrum with spinal cord which controls the movement of voluntary muscles. These nerve tracks cross the left side to the right side of the body. The medulla regulates the force and heart rate through the cardiovascular system and medullary rhythmic area of respiratory center controls the respiratory processes. Other functions are controlling reflexes for vomiting, swallowing, sneezing and coughing and hiccupping.
ANESTHESIA CONSIDERATIONS IN EPILEPSY SURGERY INTRODUCTION: Surgery for epilepsy requires a multidisciplinary approach from the neurosurgeon, the neurophysician, the neurophysiologist and the neuroanesthetist. Epilepsy surgery poses significant challenges to the neuroanesthetist. The challenges are to provide optimal operating conditions, hemodynamic stability, monitored anesthesia care for awake craniotomy and rapid emergence for neurological assessment as well as avoidance of agents which interfere with intraoperative ECoG and cortical mapping.
This case provided an excellent example of how the initial working diagnosis can change over time as further clinical, radiological and haematological information is obtained from specialised investigations. It also illustrates that association is not always causation i.e. the head injury coincides with symptom onset, yet there was no evidence of cerebellar injury on imaging. The complex nature of each individual’s health can be seen in this young patient. Rarely does a health problem present according to the “textbook” definition, nor do problems exist in isolation. Many patients present with one issue but have an underlying condition, such as anaemia, unearthed during investigations.