Microcrystalline Cellulose Lab Report

Abstract

The adsorption behavior of some metal ions (Pb, Mn, Mg, Zn and Ca) was studied on silicon dioxide nanoparticles alone and its mixture with microcrystalline cellulose powder (1:1) as drug carriers in pharmaceutical preparations. The effect of different conditions as temperature and pH values on the adsorption behavior was investigated. It was found that upon increasing the temperature, the ability of the adsorbent material increases. The pH of the metal solution has the same effect as temperature till pH 8. However, above pH 8 the adsorbent material began to lose its adsorption efficiency. Although, the use of silicon dioxide nanoparticles mixture with microcrystalline cellulose can improve the excipient functionality, it is important

They are chemically inert with a good biocompatibility and have high surface area and pore volume [Arayne and Sultana, 2006; Barbe et al., 2004]. They enhance the dissolution rate of drugs by adsorption of drug molecules on the surface and pores of the silica carrier using Van der Waals forces and hydrogen bonds. When in contact with water, these bonds can be easily broken to release the drug molecules [Hu et al., 2014; Zhang et al., 2011; Uejo et al., 2013; Barman et al., 2014]. They also provide a targeted drug delivery system which decrease the non-target tissue and cells toxicity and give the best therapeutic effect. Moreover, NPs decrease the doses needed of the drug consequently decreases its toxicity [Kwon et al., 2013; Vivero-Escoto et al., 2010].

However, concerning the safety of silica nanoparticles (SiO2 NPs), it is reported that SiO2 NPs can lead to dose-dependent cytotoxicity, lung inflammation and nephrotoxicity [McCarthy et al., 2012; Napierska et al., 2010; Passagne et al., 2012; De Simone et al., 2013; Sheet et al., 2014]. Metal-based nanomaterials are risk factors for lung diseases, as these metals have fibrogenic, inflammogenic or carcinogenic effects in