Metho Case Study

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7110 Afr. J. Biotechnol.

DISCUSSION

Methomex (Metho) application as an insecticide is highly effective against a wide variety of pests, particularly those that are resistant to organophosphorus (Farré et al., 2002). Metho exerts its toxic effect via peroxidative damage to the hepatic, renal and splenic cell membranes and induces DNA damage in these organs (El-Khawaga, 2005). Kid-neys are responsible for the elimination of metabolic waste and the control of the amount and composition of the body fluids. Nephrotoxicity can result in systemic toxicity causing decreased ability to excrete

Figure 10. Photomicrograph of the renal medulla, from kidney rats administered with GSO+1/10 LD50 Metho showing the normal structure of the collecting tubules

This damage was more pronounced in the higher dose which may cause renal failure. However, co-administration of the extracts of protective plants resulted in minimizing the deleterious effects of metho-mex toxicity on male renal tissues. It may be concluded that grape seed oil is useful as a herbal remedy, espe-cially for controlling oxidative damages.

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