Methocarbamol Case Study

What Patient population would you use this drug for?

Methocarbamol is a skeletal muscle relaxant which is used in the population who is suffering from

• Low back pain

• Musculoskeletal chest pain

• Stiff person syndrome

• Persistent pain in adult patient

What is neuroplasticity means?

Neuroplasticity is the define as a production of new neural pathway to adapt as it needs. This process is ongoing throughout the lifetime. Neuroplastic changes can occur at the small scale like physical changes to individual neurons or the whole brain like cortical remapping in response to the injury. Neuroplasticity is recognised by two different terms: syneptic neuroplasticit, which refers to changes in how neurons connect to each other, and non-synaptic plasticity,

Stimuli initiating a nociceptive response vary, but receptors and endogenous defence mechanisms in the periphery interact in a similar manner regardless of the insult. Chemical, mechanical, and thermal receptors, along with leucocytes and macrophages, determine the intensity, location, and duration of noxious events. Noxious stimuli are transduced to the dorsal horn of the spinal cord, where amino acid and peptide transmitters activate second-order neurones. Spinal neurones then transmit signals to the brain. The resultant actions by the individual involve sensory-discriminative, motivational-affective, and modulatory processes in an attempt to limit or stop the painful process. Under normal conditions, noxious stimuli diminish as healing progresses and pain sensation lessens until minimal or no pain is detected. Persistent, intense pain, however, activates secondary mechanisms both at the periphery and within the central nervous system that cause allodynia, hyperalgesia, and hyperpathia that can diminish normal functioning.

What is CNS Depressants?

A depressant, by definition, reduces or diminishes a function or activity. A CNS depressant, therefore, would depress the activity of the central nervous system (CNS). Some drugs that are commonly used as sedatives, hypnotics (sleep aids), and anesthetics are CNS depressants. There are numerous CNS depressant drugs;