Degradation study of Product 01 using Aqueous 1N NaOH solution .The mechanism is operated by hydrolysis. The hydroxyl group (-OH) of NaOH attacks an electrophilic carbon of >C=O group which an removal of tertiary Nitrogen gives 4-MBA and PD as by products. Degradation study of Product 02 using Aqueous 1N NaOH solution . The mechanism is operated by hydrolysis. The hydroxyl group (-OH) of NaOH attacks an electrophilic carbon of >N-C=O which as rearrangement gives carbonial .
Lab Report 10: Nitration of Bromobenzene Raekwon Filmore CM 244 Section 40 March 27, 2018 Introduction: For this experiment, nitration of bromobenzene was the focus of the lab. The benzene is an aromatic compound and when it reacts with wither a mixture of sulfuric acid or nitric acid creates what is known as a nitro group. The formation of the nitro group is possible because it is an electrophilic aromatic substitution reaction. The creation of the nitronium ion is shown below: The reaction with the nitronium ion with bromobenzene creates three products instead of one. Depending on where the nitronium group or the alpha complexes of the reaction is on the ring, determines whether the product will be meta, para or ortho.
After the nucleophilic substitution, the nucleophile can be neutral or carry a negative charge while the substrate can be neutral or positively charged. In this lab, a primary alcohol is converted to an alkyl bromide and a benzyl chloride into an ester using the SN2 reaction. Factors affecting the rates of both SN1 and SN2 reactions will also be investigated. In 1935, two scientists by the names of Sir Christopher Ignod and Edward D. Hughes, studied nucleophilic reactions of alkyl halides. Ignod first grouped organic reactions
3. To purify and identify the product, recrystallization is used in order to purify the product, then melting point and TLC techniques are used to identify the product. Theory 4. In nucleophilic substitution reactions, there are two possibilities, either Sn1 or Sn2. In this particular experiment, an Sn2 reaction
Dehydration of 2-Methylcyclohexanol Sura Abedali Wednesday 2:00 PM January 31, 2018 Introduction: Dehydration reactions are important processes to convert alcohols into alkenes. It is a type of elimination reaction that removes an “-OH” group from one carbon molecule and a hydrogen from a neighboring carbon, thus releasing them as a water molecule (H2O) and forming a pi bond between the two carbons1. In this experiment, 2-methylcyclohexanol undergoes dehydration to form three possible products: methylenecylcohexane, 1-methylcyclohexene, and 3-methylcyclohexene in a Hickman still apparatus. Adding 85% Phosphoric Acid to protonates the “-OH” group, turning it into a better leaving group and initiating the dehydration reaction. The dehydration of 2-methylcyclohexanol takes place at the bottom of the Hickman still.
X.Huang et al.  studied gas-phase hydrogenolysis of methyl formate at atmospheric pressure over two type copper based catalyst, copper chromite and skeletal copper. The product where analyzed by GCs with TCD, Porapack Q column and CTR-1. Before use the catalyst was reduced, the skeletal catalyst was heated to 483 K with H2 flown over for 1-2hour, while the copper chromite catalyst was heated to 513 K with H2 flown over for 4 hour. For the experiment the amount of catalyst was around 0,5g skeletal copper and 0,15 g copper chromite.
CH3 175 83.06% 287-289ºC 4. -OCH3 191 86.03% 275-277ºC 5. 204 78.78% 295ºC Step-3 Synthesis of 2-Methyl benzoxazin -4(3H)-one53 (4) Anthranilic acid (0.1M, 18g) was taken in acetic anhydride and refluxed under anhydrous conditions for 4 hrs. Excess of acetic anhydride was then distilled off under reduced pressure. Obtained product was immediately used for next step.
The IUPAC nomenclature for haloperidol is 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one. Figure 1: 2-D structure of haloperidol (taken from https://pubchem.ncbi.nlm.nih.gov/compound/3559) Tacke et al (2008) analysed haloperidol in order to determine the physicochemical properties of the drug. At a pH of 7.4, it was discovered that haloperidol has a distribution coefficient (Log D) of
3.3. Synthetic methodologies for dihydropyrimidinones 3.3.1. Classical method Scheme-1: The conventional method for the synthesis of DHPMs is the one-pot three-component reaction of benzaldehyde, ethyl acetoacetate and urea in the presence of an acid catalyst. The product of this novel one-pot, three components synthesis that precipitated on cooling of the reaction mixture was identified as 3,4-dihydropyrimidin-2(1H)-one and this reaction came to be known as “Biginelli reaction”, or “Biginelli condensation”, or “Biginelli dihydropyrimidine synthesis” after the name of its inventor “Pietro Biginelli”.1 Mechanism Forty years after Biginelli’s initial report, the first mechanism for the synthesis of DHPMs was conducted by Folkers and Johnson
The N‟-2- (bromophenyl)-N,N-dimethylurea 16 underwent lithiation on the nitrogen to form a monolithio intermediate using MeLi, followed by bromine-lithium exchange using t-BuLi to give the dilithio species 17. 14 The intermediate 17 was then exposed to carbon monoxide to give 18, which after cyclization forms the intermediate 19, followed by loss of LiNMe2 to give 20, and finally after work up with dilute acid yielded the isatin product 1. 1 13 14 15 6 N O O 1) MeLi, 0 C CO Br N H O NMe2 2) t-BuLi, 0 C Li N O NMe2 Li C N Li O Li O NMe2 N O NMe2 O Li Li -LiNMe2 N H O O Li H3O + X X X X X X A rather versatile and novel two step synthesis of isatins was presented by Mironov in 2001 and allowed for the preparation of isatins containing electron withdrawing groups such as - CF3, -NO2, and -Cl. The method is based on the reaction between aromatic isocyanides and tertiary amines,15 where in the first step, 2-triethylammonio-3-arylaminoindolates 23 were obtained from the corresponding aromatic formamides 21 without isolation of the intermediate isocyanides 22. 16 Heating the 2-triethylammonio-3-arylaminoindolates 23 in excess thionyl chloride followed by hydrolysis led to the target