RESULTS AND DISCUSSION Preformulation Studies The melting point of Metoprolol Tartrate was determined by capillary method and was found to be 121ºC (120 - 124ºC) as reported in literature, thus indicating purity of Metoprolol Tartrate. FTIR analysis showed that all the characteristic peaks of Metoprolol Tartrate and mixture of Metoprolol Tartrate with excipients were present in the range of reported frequencies; which shows that drug and excipients were compatible with each other. DSC thermogram of Metoprolol Tartrate alone showed endothermic peak at 120.73°C, corresponding to the melting point of the drug. The thermal curve of the Metoprolol Tartrate obtained indicated its crystalline anhydrous state, exhibiting a sharp endothermic peak at 120.73°C. The …show more content…
s q. s q. s q. s q. s q. s Table no.1 Formulation Table Table No.2: Physicochemical properties of the prepared buccal patches of Metoprolol Tartrate Formulations Folding Endurance* Tensile Strength* (%) Percentage Elongation* (%) Percentage Moisture absorption* (%) Percentage Moisture loss*(%) Drug Content* (%) F1 315 ± 2.516 38.72±1.10 143±1 3.89±0.67 1.5±0.82 91.64±1 F2 326 ± 2.081 46.71±1.505 122±1 4.19±0.75 1.4±0.97 94.60±1.174 F3 328 ± 2.645 42.43±0.735 121±1 5.11±0.94 2.1±0.65 93.25±0.960 F4 318 ± 1.527 49.34±1.01 142±1 3.75±0.81 1.3±0.23 97.80±0.990 F5 345 ± 2.081 46.93±2.16 125±1 4.69±1.32 2±0.71 90.60±0.995 F6 358 ± 2.081 51.31±1.00 134±1 3.45±0.84 1.5±0.84 89.03±1.000 *Data expressed as mean ± SD
Limaye PMCY 6510 Take Home Final Exam Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is a white to off-white crystalline compound with a molecular formula of C4H11N5•HCl and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. Metformin belongs to BCS class III with high solubility and low permeability. This also allows for designing a controlled release formulation of metformin hydrochloride. However, due to the high dose amounts and dosing frequency, it has been a challenge to develop once daily metformin formulation.
Discussion 1. Zn0 (s)+ Cu2+S6+O42-(aq) →Cu0(s) + Zn2+S6+O42-(aq) Zn0(s) → Zn2+(aq) + 2e- Cu2+(aq) + 2e- → Cu0(s) Zn0(s) + Cu2+(aq) → Zn2+(aq) + Cu0(s) Oxidant (oxidizing agent) is the element which reduces in experiment.
Suppose you need to find the fractional European call and the fractional European put options. Let the Hurst parameter be $H=0.85$, the $\sigma=0,25$, $r=0.10$, $S_{fbm} = 100$, $K = 95$, we have \begin{eqnarray*} d_1^{fBm} & = & \frac{\ln{\frac{S}{K}} + \frac{1}{2}(r( T - t) + \frac{(1)\sigma^2{( T^{2H} - t^{2H})}}{2})}{\sigma{\sqrt{T^{2H} - t^{2H}}}}\\ & = & \frac{\ln(\frac{105}{100}) + (0.10(0.25 -0) + \frac{(1){0.25^2}{0.25^{2(0.85)} - (1)0.25^{2(0.85)}}}{2}}{(0.25){\sqrt{0.25^{2(0.85)} - 0}})} \end{eqnarray*} we obtain $d^{fBm}_1= 1.0558$. We find in the normal distribution that $N(1.0558)= 0.8544$ and $N(-1.0558) = 0.1456.$
75 90 Doc 1 1.31556 1.80357 1.80357 Doc 2 1.75182 1.87012 1.87012 Doc 3 2.13338 2.27178 2.27178 Doc 4 1.56941 1.0743 1.0867
In this lab, 3-chloro-3,7-dimethyloctane, obtained during a pervious lab, was used to understand the E2 dehydrohalogenation reaction of an alkyl halide. This reaction is possible because 3-chloro-3,7-dimethyloctane contains a carbon-halogen bond, and the chlorine attached to the molecule is a good leaving group. In the dehydrohalogenation of 3-chloro-3,7-dimethyloctane, 1.320g of the starting compound was obtained. This was then added to a mixture of boiling 6mL ethanol and1mL potassium hydroxide. This solution was then heated for 15 minutes until a precipitant formed.
The following lab period the solid was weighed (0.0483 g) and percent yield was calculated (65.5%) with the limiting reagent being tetraphenylcyclopentadienone. The melting point was determined. The first melting point was 204-204.9 °C and the second melting point was 215.6-215.9°C. Finally, an infrared spectroscopy was obtained for the
What Patient population would you use this drug for? Methocarbamol is a skeletal muscle relaxant which is used in the population who is suffering from • Low back pain • Musculoskeletal chest pain • Stiff person syndrome • Persistent pain in adult patient What is neuroplasticity means?
A human heart cDNA library was screened with a probe corresponding to the mouse PPARg (7). Three overlapping clones were identified, purified, and sequenced. The nucleotide sequence is shown in Fig. 1. The longest open reading frame starting from the nucleotide at position 91 coded for a polypeptide of 505 amino acids.
The chemical and physical properties of a variety of chemicals work together to form a desired end product that is used commercially. Three chemicals that are used to form a bouncy ball in this experiment were; Polyvinyl Alcohol, Polyvinyl Acetate, and Borate. Polyvinyl Alcohol is a water-soluble polymer that is commercially used for paper and textiles products (Polyvinyl Alcohol PVA chemical Compound). Polyvinyl Alcohol is unique polymer, for it is only created with the dissolving of another polymer such as Polyvinyl Acetate, through hydrolysis (Polyvinyl Alcohol PVA chemical Compound).Polyvinyl Alcohol is an adhesive element. With the application of polyvinyl acetate that is formed from polyvinyl alcohol; is used as an adhesive in Elmer’s
7) Empirical Formula Figure 17: Chemical Structure of Mannitol 8) Applications in Pharmaceutical Formulation or Technology Mannitol is widely used in pharmaceutical formulations and food products. In pharmaceutical preparations it is primarily used as a diluent (10–90% w/w) in tablet formulations, where it is of particular value since it is not hygroscopic and may thus be used with moisture-sensitive active ingredients. Mannitol may be used in direct-compression tablet applications, for which the granular and spray-dried forms are available, or in wet granulations. Granulations containing mannitol have the advantage of being dried easily. Specific tablet applications include antacid preparations, glyceryl trinitrate tablets, and vitamin preparations.
Abstract The unknown concentration of benzoic acid used when titrated with standardized 0.1031M NaOH and the solubility was calculated at two different temperatures (20◦C and 30◦C). With the aid of the Van’t Hoff equation, the enthalpy of solution of benzoic acid at those temperatures was determined as 10.82 KJ. This compares well with the value of 10.27KJ found in the literature.