Specific Aims/Hypothesis(es) to be tested
Bacterial Vaginosis (BV) is the most common cause of vaginal symptoms among women of reproductive age, ages 15-44 years. The number of lactobacilli in the vagina of women with BV is significantly lower than that in healthy women. While some women may be asymptomatic, most experience thin, white or yellow abnormal vaginal discharge and malodor, especially after intercourse. Women with BV have an increased risk of many gynecological complications. Bacterial infections have been linked to increased risk factors for many sexually transmitted infections (STIs), including human immunodeficiency virus (HIV) infection. Women may also de-velop increase risk of second trimester miscarriage, preterm birth,
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Specific Aim 2: Document and compare adverse effects of the proposed probiotic IUD with that of metronida-zole.
Hypothesis 2: Fewer adverse events will be documented with the use of a probiotic-eluting IUD than with the typical BV treatment of metronidazole.
Specific Aim 3: Cost Analysis: Compare the costs (device, treatments and ob/gyn visits) associated with the new probiotic-eluting IUD versus typical treatment for bacterial vaginosis.
Hypothesis 3: The long term cost of treating bacterial infections in hormonal IUD users will be lower in those using the proposed probiotic housed intrauterine device.
Expected outcomes are that a hormonal intrauterine device containing Lactobacillus acidophilus will be more effective, and more cost effective than traditional treatment of metronidazole for treatment of bacterial vagi-nosis (BV) in IUD users. A steady intrauterine absorption of probiotics during early use of an IUD may reduce the incidence of a bacterial infection as well as prevent recurrence. In the long-term, this may reduce risk fac-tors for gynecological complications, viral transmission, and complications during
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BV is a condition characterized by vaginal flora imbalance, in which normally plen-tiful peroxidase-producing bacteria (Lactobacillus) are scarce and other anaerobic bacteria abundant. Among women presenting for care, BV is the most prevalent cause of vaginal discharge or malodor; however, in a nationally representative survey, most women with BV were asymptomatic. [1] BV is as-sociated with an increased risk of acquisition of sexually transmitted infections (STIs), HIV, and with ad-verse pregnancy outcomes. Although BV is associated with an increased risk of acquisition of STIs, da-ta from a 2007 study support the conclusion that bacterial vaginosis is not exclusively a sexually trans-mitted condition. [2] The prevalence in the United States is estimated to be 21.2 million (29.2%) among women ages 14–49, corresponding to 21.4 million women with BV. [1] Risk factors for acquiring BV in-clude black race, sexual activity, douching, and cigarette smoking.
UnityPoint OB/GYN Clinic is a non-profit four-physician practice located in an urban area of Fort Dodge, Iowa. The current practice within this clinic for pregnant women is at their first prenatal visit with the nurse they receive a large packet of information. This packet contains printed educational information, pamphlets, and a 200-page book. This information is not reviewed with the patients prior to leaving this appointment. This is the only prenatal visit that written educational information is given unless the patient requests more.
The vaginal tract is the most susceptible site when compared with the other mucosal sites such as oral and anal sites (16, 17, 34, 36). To obtain the robust and unbiased results, we will include up to six samples (3-4 samples are commonly used for this kind of study) of each group for RNA sequencing. To minimize the variables in the study, we plan to use the inbred mouse strain (NU/J-Foxn1nu/J). To minimize the variation in age, the siblings of the infected mice without infection will be used as negative controls. In Specific
On the other hand, let’s investigate a story on Dr. Atul Gawande a surgeon and New Yorker staff member, “More than a decade ago, I saw a young woman in the emergency room who had severe pelvic pain. A standard X-ray showed nothing. I examined her and found signs of pelvic inflammatory disease, which is most often caused by sexually transmitted diseases. She insisted that she hadn’t been sexually active, but I didn’t listen. If I had, I might have ordered a pelvic CT scan or even recommended exploratory surgery to investigate further.
Chlamydia prevalence was 1.7% among persons aged 14–39 years in the United States. Among sexually active females aged 14–24 years, chlamydia prevalence was 4.7% overall and 13.5% among non-Hispanic blacks. In the United States, a survey was done on the number of people infected with chlamydia. Of the 8,330-sample size, 2,721 people who were infected were in the age group of 14-19 years old, that is a prevalence percentage of 2.4. You are only 18 years old, you could be one of those infected
The subjects were not knowing that the bad blood was contagious and how the disease was transmitted. Researcher did not explain them that the disease was passed on from females to
Among the millions of Americans that are sexually active a sweeping pathogen is hard at work. Chlamydia, a sexually transmitted bacterial infection, has topped the list on a global scale as being the most prevalent sexually transmitted infection (STI). One of the key reasons for this is that this bacterium has the ability to go unnoticed, and as a result, leaves in its wake numerous infected hosts who in turn unknowingly spread the disease further. Screening practices for chlamydia along with education about reproductive health and human sexual behavior are lacking in impoverished regions and without these preventative measures chlamydia continues to gain a foothold.
Chlamydia Chlamydia is a sexually transmitted disease caused by a bacterium called Chlamydia trachomatis. Not all people contaminated with chlamydia have symptoms, so the infection can go unnoticed for many years. Patients with asymptomatic chlamydia become permanent sources of contamination, which is why chlamydia is the most common STD in the world. Whoever transmits chlamydia may not know that it is contaminated and whoever gets contaminated may not know who infected it.
(Kathleen Smith, 1996-2018). All in all, it is an illness that is not very dangerous, it can get serious if not taken care of when it first comes about in an individual’s life, it can lead to other illnesses, or suicidal thoughts if it does get too far. People are going to get sick and they will come into a counter with germs, but getting a diagnosis, and then finding a cure is always a great start, that way you live a stress-free life. (WebMD LLC,
Human Papillomavirus (HPV) is currently the most common STI in the United States.1 HPV is a public health concern because of its potential to cause multiple types of cancer including oropharyngeal, cervical, vulvar, vaginal, penile, and anal cancer.2 From 2004 to 2007, 25,110 out of 32,456 cases of such cancers were attributable to HPV.3 Precancerous growths and genital warts due to HPV also burden the healthcare system. In 2012, the total healthcare burden of preventing and treating HPV diseases was estimated to be 8 billion dollars.3 HPV is spread by skin to skin contact.4 Barrier methods such as condoms and dental dams are only effective if the infected area is covered, creating a serious challenge for prevention. However, a quadrivalent
According to the Centers for Disease Control and Prevention (2012), “Among sexually-active women aged 16–24 years in commercial plans, chlamydia screening increased from 23.1% in 2001 to 45.0% in 2011. During the same time period, the screening rate among sexually active women aged 16–24 years covered by Medicaid increased from 40.4% to 58.0%. Although chlamydia screening is expanding, many women who are at risk are still not being tested reflecting, in part, the lack of awareness among some health care providers and the limited resources available to support these screenings” (n.p.). Getting tested for chlamydia requires attention and awareness on the part of medical personnel, but it also goes into the willingness of a patient to discuss their sexual history, including how many partners they have had and if they, or those partners have ever had an STD in the past. This would also provide the perfect platform to talk about the severity of the situation and to clear the air about any myths and not to lean on Google or WebMD to educate or protect the patient’s life.
This course has expanded our knowledge on the causation and effects of numerous diseases that impact the field of epidemiology. A disease that deserves utmost attention is Chlamydia as it severely affects women. This case study is enabling us to explore the effectiveness and efficiency of tests that may be used to curb the problem of this sexually transmitted disease. Chlamydia is very prevalent globally and it is feared by many and yet still there are so many unreported cases of the disease. According to research from the CDC, Chlamydia is a common STD that affects both men and women and can cause serious damage to the reproductive system of women and furthermore lead to potentially fatal ectopic pregnancy presenting a problem for women
Some women have complications after starting their IVF process, “one of the major complications we
In the academic discourse, from Annal of Internal Medicine by Kalyani Sonawan chose to use a very authoritarian tone to provide research on how men are being infected by HPV more than women. In this article, there were very unfamiliar words that can be very difficult to pronounce and understand. I am sure that a scientist would have no problem understanding the diction the author chose. There weren’t any opinions or feelings stated in this article about how the impact of HPV could impact the people who were infected and their families. It briefly mentioned the symptoms and risk of someone who is infected but not in depth.
If only one individual that has a sexually transmitted disease has sexual relationships with many other people, he/she’ll most probably infect the entire
The World Organization appraisal that around the world over a million people are infected every day with a STD. 50,000 of those cases are in the United States of America alone. Some examples of transmitted diseases