Microbial Evolution – Staphylococcus aureus
Name: Sean Lin Class: E8J Date: May 23th, 2016
Introduction:
Staphylococcus aureus is a species of bacteria that belongs to Staphylococcus genus, and it is generally found in the nose, respiratory tracks and on skin. Staphylococcus appears as a form like a grape clusters when looking through a microscope, and it has large, golden colonies. Staphylococcus reproduces by binary fission, which it is asexual. [Cashin, 2010] The symptoms on humans that are caused by the infection of Staphylococcus aureus consist a very wide range, from minor skin problems such as boils or abscesses, to life threatening diseases such as pneumonia, endocarditis or meningitis.
Staphylococcus aureus has been a great concern
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The most common treatment for these infections, caused by Staphylococcus aureus is the antibiotics. There are many kinds of antibiotics using in the modern days, but the first kind of antibiotic being introduced for treating Staphylococcus aureus was Penicillin in 1943. This kind of antibiotic stops the formation of peptidoglycan cross-linkages that makes the bacterial cell well stronger. This eventually makes the cell wall formation and degradation become imbalanced, consequently lead to the cell to die. Other kinds of antibiotic were quick introduced for treating Staphylococcus as well. As more kinds of antibiotics were introduced and people widely used them to kill Staphylococcus aureus bacteria, they become the selective pressure for the …show more content…
However, the amount of Staphylococcus aureus that is antibiotic resistance gradually increased, until the year of 1950, the number rose to 40% of the patients, and 80% of the patients until the year 1960. The mechanism that made the bacteria become resistant to the antibiotic is that, a mutation to an extremely small amount of Staphylococcus aureus. From this mutation the bacteria began to produce an enzyme called penicillinase, which it breaks the molecule within penicillin that makes the antibiotic to function. Consequently, this antibiotic become ineffective and the bacteria eventually survived. This kind of Staphylococcus aureus is called “MRSA”, referred to methicillin-resistant S. aureus. This bacteria are multi-resistant to beta-lactam antibiotics, meaning that they are resistant to different kinds of antibiotics, such as penicillin, methicillin, dicloxacillin and cephalosporin. As the process goes, that normal Staphylococcus aureus are being killed by penicillin antibiotic, and the ones that are resistant survived and keep on reproducing, Staphylococcus aureus bacteria that is penicillin resistant spread in the community and its amount kept on increasing. This made natural selection to occur, which the bacteria that are antibiotic resistance are suitable ones and they survived in
Section 1: Identification of the unknown pathogen Patient is Terrance V. Haller, a 13-year-old male who enjoys outdoor activities such as skateboarding. No previous medical history and there are no known allergies. Terrance had a skateboarding accident where there were multiple lacerations and contusions. The wound on his forearm extending to his elbow was slow healing and therefore became pus producing. The patient has since returned to his primary care physician to find out what is going on.
Hunting nightmare bacteria Answer the following questions Case of Addy (the girl from Arizona ) 1- Based on the pediatrician observations what was Addy’s diagnosis at the Pediatric Hospital intensive care unit ? She had got infected by staff or positive bacteria called Methicillin-resistant Staphylococcus aureus (MRSA). MRSA is a community associated bacteria that infects kids when they are playing in playing ground and getting scabs on their knee. They spread through that wound and it has very high resistance to antibiotics.
“Antibiotic sensitivity tests showed that the two groups differed in sensitivity to penicillin and erythromycin, but no other antibiotics.” (Article abstract).Out of the nine hundred samples they took, the group showed the bacteria was defeated by the antibiotic penicillin and the antibiotic erythromycin but the other antibiotics didn’t touch the bacteria. The experiment showed people only two antibiotics were fighting off the bacteria. The two of which are being over used and over time will no longer work. If the bacteria continues to grow bigger and better, the antibiotics for ear infections aren’t going to work which leads to hearing loss, even to the extent of going
Inflammation is the main type of innate immunity our body uses against A. schmiddy. Inflammation begins by activating acute-phase proteins, and soon after vasodilation occurs, followed by redness, swelling, pain, and heat. Once vasodilation occurs, histamine and kinins are released and blood vessels permeability is increased, causing white blood cells to report to the infected area. One problem associated with inflammation is that the capsule of A. schmiddy is an important virulence factor, which helps the bacteria to resists phagocytosis. Because the phagocytes cannot destroy the bacteria cells, infection further continues and necrotic tissue forms.
PHAR 100 Assignment 3 1. Antibiotics are a form of medicine that seek out and destroy the bacteria that make us feel sick. Antibiotics work great against bacteria, however they don’t work against viruses. Penicillin was the first antibiotic to be discovered by Alexander Fleming, and it was first used to treat infections. Essentially, these powerful medicines fight bacterial infections, and have the potential to save lives.
Florey and his colleagues at Oxford developed the antibiotic use for the penicillium mold however because Britain was under siege, they did not grant any funding or support. This lead to Florey and his colleagues going to the US for help which they gladly offered. The US gladly granted it and Florey and his colleagues began testing and eventually came up with an antibiotic. They began testing in 1942 and a year later, it entered the war. It was a game-changer because it was universal to many infections and later on, became cheap and abundant.
Another medication developed was penicillin. “Before the widespread use of antibiotics like penicillin in the United States, even small cuts and scrapes could lead to deadly infections.” (Little, 2021). This is why penicillin was such a good thing. Now soldiers didn’t have to worry as much if they got wounded in battle.
The people that are most susceptible to get Staphylococcus epidermidis are newborns, the elderly, immunocompromised patients, and patient’s who are using a catheter. This is because newborns and the elderly do not have as strong of immune systems as children and middle-age adults
Moreover, Penicillin, a group of antibiotics, was discovered during this time, specifically in the 1928s by Alexander Fleming (ACS, 2023). Although the first dose of penicillin was used in 1941 by Albert Alexander, it was still a life-changing discovery as it changed the lives of many - even after the period of 1918s1939s (Wood, 2010). The discovery of penicillin allowed a lot of life-threatening diseases to be treated, such as bronchitis, tonsillitis, and pneumonia. Penicillin is known to save millions of lives. Indeed, in just World War Two, the death rate because of bacterial pneumonia would go from 18% to 1%, because of the invention of penicillin.
Even though antibiotics can be very beneficial in curing infections and saving lives, the careless, mishandled use of these drugs are a major threat to society. Resistance comes with evolution and humans need to be careful not speed up this process. Just like Ricky Lannetti, even the healthiest of people can be affected by antibiotic-resistant bacteria. Bacteria resistance is not slowing down anytime soon, so it is up to the human race to become responsible for their applications of these powerful drugs. Theresa Drew was able to voice a warning after the death of Ricky, “My only son was killed on December 6th, 2003.
Staphylococcus Aureus belongs to the extremely common bacteria of microflora of the skin and mucous membranes of the humans. These pathogens cause many infections, including superficial and deep purulent infections, poisoning, urinary tract infection etc. In the US, staphylococcus bacteria are supposed to be the leading cause of sepsis, postoperative wound and prosthesis infections. In addition, staphylococcus belongs to one of the leading causes of bacterial food poisoning. Staphylococcus Aureus is one of the most dangerous human pathogen.
During World War 2, huge medical advances took place. The war naturally gave a push to the medical world to advance in medicines that would save many lives. They made treatments for soldiers who has had severe wounds. Those treatments fell under a new class of drugs called Sulfanilamide1, which provided effective treatments for bacterial diseases like pneumonia and meningitis. One of the safest and active antibacterial available, Penicillin, was a huge medical advancement that was invented during the war.
The infection death rate of the Allies vanished amid WW2 when penicillin
INTRODUCTION: In this experiment I was testing for antimicrobial sensitivity of Staphylococcus epidermidis by using the Kirby-Bauer Diffusion test. The three antibiotics utilized in this lab were: gentamicin, novobiocin, and penicillin. I determined the effectiveness of the antibiotic by observing and measuring the zone of inhibition for each antibiotic.
As the name order, it is settled into Staphylococcus genus and S. Epidermidis species. S. Epidermidis makes its home on human skin, mucosal layer and nasal mucosa. Diseases can be taken form in human body and warm-blooded animals such as septicemia and endocarditis. In fact, S. Epidermidis is not too harmful on healthy tissue. The infection often occurs on newborn baby, drug users, and older people and those who need to use assistant devices on every part