Mitotic Catastrophe Research Paper
Mitotic catastrophe is defined as a type of cell death driven by abnormal mitosis with apoptotic features, although differences in cellular structures and protein profiles of cells were reported between these deaths20. As DNA fragmentation is a hallmark of apoptosis, where it directly reduced cell viability, and given that DNA repair machinery is inefficient during mitosis, probably because mitotic chromosomes are highly condensed21, we postulated that DNA fragmentation might occur during chronic mitotic arrest and lead to the eventual cell demise. This postulation is further reinforced by our previous data which suggested a decrease in chromosomal compactness, thereby implying an increase in its susceptibility to DNase. Therefore, we investigated
Bio 655 Week 1 Lab Report
1378 Words | 6 PagesThe study also found that an increase in γ-H2AX (a marker for DNA double-strand breaks) and a decrease in RAD1 (a marker of HR directed DNA repair) focus-positive cells was associated with a depletion of MEN1 expression as predicted. The study also predicted that NHEJ could function to repair double strand breaks, and would increase with a loss of MEN1 functionality. The study found this prediction to be true. The study also investigated the role of ATM and ATR DNA damage kinases in relation to MEN1, and found that MEN1 is protected from ubiquitin mediated degradation through phosphorylation by ATM and ATR protein kinases. One of the most significant results from this study involved determining the functional relationship between the expression of HR target genes and MEN1, as well as investigating the mechanism of action involved in the cellular process.
Summary Of A Magnificent Catastrophe By Edward J. Larson
943 Words | 4 PagesAt the turn of the 18th century, America had faced a troubling election that would give them a very different experience than the previous elections. In the novel A Magnificent Catastrophe, Edward J Larson depicts the thrilling story of the election of 1800, an election that has, in essence, establish the political system that has since shaped the way modern politics is handled. Larson goes into depth on the political race that would establish the creation of a two-party system and inform the reader on the election that held the first real presidential campaign. In an intriguing tale of the clash between two completely different ideologies, Larson informs us on the drama and convulsions of the election of 1800. Demonstrating exactly how Vice
The Sixth Extinction By Elizabeth Kolbert: Chapter Analysis
1698 Words | 7 PagesJessica Toppins Dr Burbery Eng 210 8 Apr 15 Title In the making of The Sixth Extinction, author Elizabeth Kolbert travels to corners of the Earth in search of evidence to support her theory that humans are the cause of the next big extinction. In her travels she visits the remote yet widely known, One Tree Island. While the name is not representative of the tree population on the Island, Kolbert found that the island has many other extraordinary qualities that are both beautiful and frightening.
A Magnificent Catastrophe Summary
852 Words | 4 PagesCritical Book Review: A Magnificent Catastrophe In A Magnificent Catastrophe by Edward Larson, he showed how the young nation of America was during the crazy election of 1800. This election was characterized like so because America had not really established itself yet. America was a young nation that was only partially defined in a sense. This informative piece of work featured two opposing sides with one goal, how American politics worked back then and how people schemed to make it to the top of this never ending cycle of the quest to become one of the most important individuals in the country.
Mittelberg's Argument Against Abortion
686 Words | 3 PagesMittelberg’s speech was effective in its argument against abortion. He was able to achieve this by filling his speech with emotion and coupling these emotions with logical arguments. His hook about common misconceptions society accepts as truths, and relating it to his topic about abortion was fluid and humorous. Additionally, his use of citing outside sources helped build his argument but did not overpower the audience. By breaking his speech into three myths about abortion, Mittelberg was able to state, and then proceed to refute these myths in a very structured way.
Blastocystes: A Short Story
920 Words | 4 PagesOne day, a complete imbecile human, Chazz Micheal Micheals ate a gummy bear after it had been on the ground for 7 seconds, that's 2 more seconds then the usual 5 second rule. What Chazz didn't know why when he ate that now contaminated delicious gummy bear that he was ingesting tons of Blastocystis And three of those Blastocystis brothers named Ricky Bobby the youngest of the brothers, Jackie Moon the middle child and Ron Burgandy the eldest of all the brothers, and their plan was to get over the bridge and take over Chazz’s body. there was only one thing in the way, a muscle cell named Allen Gamble,he was a small muscle cell in chazz's body, but he still had a lot of work to do before he could beat the Blastocystis. He Knew he had to go through
Nt1310 Unit 1 Writing Assignment
852 Words | 4 PagesIn which case, the nuclear envelope is visible again and the DNA uncoil into chromatin. No DNA replication occurs during interphase II. In prophase II, the nuclear envelope disintegrates again, and the chromosomes stay in sister chromatid form (if they unraveled into chromatin during interphase II they condense again). In metaphase II, spindle fibers from opposing poles of the cell attach to the centromeres of each sister chromatid. Sister chromatids are two identical copies/strands connected by one centromere that results from the replication of a chromosome during the S phase.
Analysis Of The Metamorphosis
716 Words | 3 PagesMetamorphosis On July 3, 1883 born Franz Kafka in Prague who known as an author that writes novels and short story in language of German. He was brought up in family of middle-class in Kingdom of Bohemia capital with the ability of speaking Jewish in German. In his life mostly, the reality about the Prague’s population speaks Czech together with the separation between German and Czech speaking person are competing by themselves to make their identity strong enough where in his works such as “The Metamorphosis”, The Trial” and “The Castle” can be seen the portrayal of the society with alienated archetypes, the brutality of psychological with physical, the conflict between the parents and child and terrified quest by the characters. The community of Jewish often stuck in middle of the two cultural where will questioning about to whom a place is belong to and Kafka considers the German as his mother tongue language is fluent in the two languages.
Lord Of The Flies Survival Analysis
1289 Words | 6 PagesInstinct for Survival in Lord of the Flies Surviving! It is the goal of every species, including humans. Some achieve it and others do not. It will depend on their organization as a species, their strength, environment, and survival skills. Surviving is defined as remaining alive under adverse or unusual circumstances.
Emily Martin The Egg And The Sperm Summary
363 Words | 2 PagesEmily Martin’s “The Egg and the Sperm” (1991) highlights the use of “gender stereotypes” often used in the scientific discussion. Martin, an anthropologist at New York University, has extensive knowledge regarding the cultural relations amongst humans and how they view one another. She specifically discusses how “female biological processes” are represented and seen as less worthy than the male processes, and the similar correlation between men and women (486). Martin discusses how different research discusses the processes in a negative view and does not correctly portray the processes equally (Martin 498). Martin uses her own credibility as well as logos and analogies to represent and assert the adverse representation of the female biological
Found A Robin's Egg Analysis
59 Words | 1 PagesAlthough the narrator only found the empty shell, the author clearly states that the narrator "found a robin’s egg". A robin 's egg is fairly easy to distinguish from other local birds eggs due to its speckled surface and blue color. Thus the character did know what was in the egg, much like they know what is in their heart.
Splenomegaly Case Summary
1691 Words | 7 PagesShet, Jahagirdar and Verfaillie (2002) explain that the Philadelphia chromosome is a shortened chromosome 22 due to a reciprocal translocation between the long arms of chromosomes 9 and 22 t(9; 22q34;q11). During the translocation, the ABL proto-oncogene is relocated from its normal position in chromosome 9 to a major breakpoint cluster region - the M-BCR region located on chromosome 22 - which causes the formation of a BCR-ABL fusion gene. This fusion gene, according to Shet, Jahagirdar and Verfaillie (2002), will produce an onco-protein (p210BCR/ABL) that not just results in more tyrosine kinase (TK) activity, rather than also in increased binding to the actin cytoskeleton; an unregulated growth factor; an accelerated proliferation of leukemic hematopoietic cells; as well as an increased resistance of progenitors/precursors to apoptosis. Moreover, particularly the constantly accelerated proliferation of leukemic hematopoietic cells will increase the chance of secondary genetic abnormalities that eventually can lead to a disease progression and/or a blast crisis (Shet, Jahagirdar and Verfaillie,
Mitosis, Meiosis, Linked Genes, And Chromosomal Similarities
1226 Words | 5 PagesMitosis, Meiosis, Linked Genes, and Chromosomal Abnormalities Similarities between Mitosis and Meiosis Both Mitosis and Meiosis are involved in the reproduction of eukaryotic cells in multicellular organisms. Both start from a diploid parent cell, where the process of cell nuclear division starts with one cell. The DNA of the primary cell is replicated once prior to nuclear partitioning. Meiosis and Mitosis are multistage processes, including an Interphase, a Prophase, a metaphase, an anaphase, and a telophase, or multiples thereof. Both go through a period of growth with the interphase, and genetic synthesis, before their cycles begin.
Wheel Of Life Analysis
1293 Words | 6 PagesWheel of life The Wheel of Life also referred to as the Bhavachakra is the symbolic representation of saṃsāra (or cyclic existence). this classical image from the Tibetan Buddhist tradition depicts the psychological states, or realms of existence, associated with the unenlightened state. This painting is also translated as wheel of cyclic existence or wheel of becoming. The painting shows the summary of life and how one gets reborn and the struggle for suffering.
Mitotic Index
462 Words | 2 Pages"Mitotic index or frequency is used to determine the rate of somatic cell growth to determine if the rate of growth is abnormal (Haapasalo et. Al, 1989). " Cancer refers to any one of a large number of diseases characterized by the development of abnormal cells that divide uncontrollably and have the ability to infiltrate and destroy normal body tissue (Mayo Clinic Staff). Survival rates are steadily improving over the years with different methods being used to cure cancer. Some are good, successful fond improvements and some are fails.
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